基于中药整合药理学平台的生脉饮治疗心律失常的分子机制-药学学报.PDF

药学学报 Acta Pharmaceutica Sinica 20 18, 53 (5): 743 748 ·743 · 于中药整合药理学平台的生脉饮治疗心律失常的分子机制 1 1 2 1* 吕冬梅 , 崔如意 , 周荣荣 , 许海玉 (1. 中国中医科学院中 研究所, 北京 100700; 2. 山西中医药大学基础医学院, 山西 晋中 030600) 摘要: 生脉饮被广泛应用于心律失常并取得了很好的疗效, 由于中药复方的复杂性, 其治疗心律失常的 理学机制尚未得到阐释。本研究借助中 整合 理学平台, 对生脉饮治疗心律失常分子机制进行研究。结果显 示, 生脉饮可能通过作用于碳代谢、嘌呤代谢、糖类代谢等能量代谢相关通路或通过调节 ATP 水平来达到对心 律失常的治疗作用。本研究还得到生脉饮中发挥这一作用的主要 物成分可能是人参。 关键词: 生脉饮; 分子机制; 整合 理学; 心律失常; 人参; 能量代谢 中图分类号: R966 文献标识码: A 文章编号: 0513-4870 (20 18) 05-0743-06 Molecular mechanism of Shengmaiyin for arrhythmia based on integrative pharmacology 1 1 2 1* LÜ Dong-mei , CUI Ru-yi , ZHOU Rong-rong , XU Hai-yu (1. Institute of Chinese Materia Medica, China A cademy of Chinese Medicinal Sciences, Beij ing 100700, China; 2. School of Basic Medicine, Shanxi University of Chinese Medicine, Jinzhong 030600, China ) Abstract : Shengmaiyin is widely used in the treatment of arrhythmia and has achieved a good effect. Due to the complexity of traditional Chinese medical formula, the pharmacological mechanism of Shengmaiyin in the treatment of arrhythmia is unclear. In this study, we used the internet-based Computation Platform () to explore the molecular mechanism. Shengmaiyin was found to treat the arrhythmia by modulating the pathway related to energy metabolism such as carbon metabolism, purine metabolism, carbohydrate metabolism, or by regulating the level of ATP. In this study, we find that the main active drug component in Shengma