血细胞为供体细胞诱导iPSCs的研究进展-中国细胞生物学学报.PDFVIP

网络出版时间：2017-07-18 16:38:02 网络出版地址：/kcms/detail/31.2035.Q1638.004.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(8): DOI: 10.11844/cj cb.2017.08.0069 血细胞为供体细胞诱导iPSCs的研究进展 黄 霞 李彦欣* (上海交通大学医学院附属上海儿童医学中心转化所儿童血液肿瘤重点实验室, 上海200000) 摘要 诱导多能干细胞(induced pluripotent stem cells, iPSCs)是通过转录因子或者小分子化 合物诱导体细胞形成的形态和功能类似于胚胎干细胞(embryonic stem cells, ESCs)的一类细胞, 具 有自我更新及多向分化潜能。由于iPSCs技术不涉及传统ESCs的伦理学问题, 并且获取较为方便、 快捷, 使其在再生医学、疾病建模、药物筛选等方面具有突出的优势。经过一定时间的探索, 发现 血液细胞作为iPSCs技术的供体细胞具有很大的优势, 这也推动了对血液系统疾病的深入研究。该 文就血细胞在iPSCs诱导重编程技术中的应用以及iPSCs技术在血液系统疾病中的最新进展作一综 述。 关键词 诱导多能干细胞; 重编程; 血细胞; 白血病 Advances in Blood Cells as Donor Cell to Generate iPSCs Huang Xia, Li Yanxin* (Key Laboratory of Pediatric Hematology Oncology Ministry of Health, Department of Hematology Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China) Abstract Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells resembling embryonic stem cells which can be directly generated from somatic cells by transcription factors or small molecule compounds. iPSCs are well known for their self-renewal ability and multilineage differentiation potential with less ethical issues as compared to ES cells, and have a great advantage in regenerative medicine, disease model and drug screening. In recent years, great breakthroughs of iPSCs technology have been made in the field of hematopoietic diseases. In this review, the progress of iP