护理风险管理在冠状动脉介入治疗中的应用-齐齐哈尔医学院学报.DOCVIP

托瑞米芬联合他莫昔芬治疗晚期乳腺癌的效果观察及对肝功能和血脂的影响 宋强通讯作者 253012 德州市市立医院普外科akdhdcfye12@163.com 【摘要】目的 探讨托瑞米芬联合他莫昔芬治疗晚期乳腺癌的效果观察及对肝功能和血脂的影响。方法 选取2013年6月～2016年6月院收治的72例晚期乳腺癌患者，随机分为观察组和对照组36例。对照组采用他莫昔芬治疗，观察组采用托瑞米芬联合他莫昔芬治疗。比较两组患者的临床疗效、治疗前后肝功能水平和血脂水平及治疗后的发生情况。结果 结论 。 【关键词】乳腺；托瑞米芬；他莫昔芬；疗效分析 Curative effect analysis of Toremifene and tamoxifen in the treatment of advanced breast cancer and the effects on liver function and serum lipid 【Abstract】 Objective To investigate the clinical efficacy of toremifene and tamoxifen in the treatment of advanced breast cancer and the effects on liver function and serum lipid. Methods From June 2013 to June 2016, 72 patients with advanced breast cancer treated in our hospital were selected. All patients were randomly divided into observation group(n=36) and control group(n=36). The control group was treated with tamoxifen, the observation group was treated with toremifene and tamoxifen. The clinical curative effect、the level of liver function and blood lipid before and after treatment, and the incidence of toxic and side effects after treatment were compared. Results The effective rate of chemotherapy in the observation group (72.2%) was significantly higher than that in the control group(52.8%) (P0.05). After treatment, ALT, AST and γ-GT of two groups had no statistically significant difference (P0.05), ALP of the observation group was significantly lower than the control group (P0.05). After treatment, TG, TC of the observation group was significantly lower than the control group(P0.05), while the HDL was higher than the control group(P0.05). Nausea and vomiting, white blood cells, granulocyte decrease and thrombocytopenia incidence rate of two groups had no significant difference (P0.05). Conclusion Effects of toremifene and tamoxifen in the treatment of advanced breast cancer is explicit, can reduce the blood lipid extently, and the damage of liver function and side effects showed no enhancement, but it also need to carry on the further clinical resear