探讨慢性肾脏疾病患者血清尿酸水平与eGFR关系的性别差异.docVIP

探讨慢性肾脏疾病患者血清尿酸水平和eGFR关系的性别差异 宁夏医科大学总医院肾脏内科 付丽娜 陈孟华 摘要：目的：探讨非糖尿病慢性肾脏病患者血尿酸(uric acid，UA)与估计肾小球滤过率（eGFR）相关关系是否存在性别差异，为临床针对不同性别采用不同强度的降低尿酸方案延缓肾脏病的进展提供参考。方法：通过横断面调查，收集2010年10月-2011年7月 间宁夏医科大学总医院门诊及住院CKD1-4期患者血尿素氮、血肌酐、血尿酸等相关资料，通过线性相关性分析男女 性别两组血尿酸与eGFR相关关系 并比较两组间相关关系差异。结果：本研究共纳入CKD1-4期患者235名，进行男女性别比较，其中男性患者120名，女性患者115名，他们在年龄、BMI、平均动脉压、合并高血压病、血尿素氮、白细胞计数、血红蛋白、CRP、血钙、血磷、血清白蛋白、血清总蛋白、LDL、HDL、TG、24小时尿蛋白定量等可能影响eGFR的因素差异均无统计学意义（P＞0.05）。CKD1-4期男性、女性患者血尿酸水平与eGFR相关性分析均呈线性相关（男性相关系数=0.119，P＜0.001；女性相关系数=0.213，P＜0.001）。进一步比较男女两组间eGFR/UA，男女间差别有统计学意义（P＜0.05），且女性比值较男性高。结论：血尿酸是非糖尿病慢性肾脏病患者eGFR下降的独立危险因素且有性别差异性，对女性患者的eGFR影响更明显。 关键词：慢性肾脏病 血尿酸 eGFR Explore chronic kidney disease patients with serum uric acid level and eGFR relationship to differences of gender Nephrology department of general affiliated hospital of Ningxia medical university Fu Li-na1 Chen Men-hua2 ABSTRACT：Object To Explore chronic kidney disease patients with serum uric acid level and eGFR relationship to differences of gender.. Methods We had a Cross-section study of CKD patients stage1-4 in General Hospital of NingXia medical university between October, 2010 and July, 2011. We collected data including blood urea, serum creatinine, serum uric acid and so on. Linear regression was performed to analysis relationship between serum uric acid level and eGFR. Further analysis was performed between male and female. Results 235 patients of CKD stage1-4 including 120 male and 115 female were entered in our study. Their age, BMI, mean arterial blood pressure, hemoglobin, Serum creatinine, serum calcium, serum phosphorus, serum albumin, serum total protein and other factors may affect eGFR was no significant difference（P＞0.05）. Linear regression indicated relevance between uric acid and eGFR were significant both in male and female (Male R=.119，P＜0.001；Female R=0.213，P＜0.001). Further analysis difference of eGFR/UA was significance between male and female and even higher in female. Conclusion Serum uric acid is the independent ri