磁共振成像对重型β地中海贫血患者沉铁状态评估及铁过载发病率和铁过载严重程度研究.docVIP

磁共振成像对重型β地中海贫血患者沉铁状态评估及铁过载发病率和铁过载严重程度研究 　　【摘要】 目的：利用磁共振成像（MRI）评估重型β地中海贫血患者的沉铁状态，并探究铁过载发病率与铁过载严重程度之间的相关性。方法：以40例确诊重型β地中海贫血患者为研究对象，利用MRI评估受检者的心脏和肝脏T2*值，使用阿格斯软件分析心脏左室射血分数。结果：重型β地中海贫血的沉铁状态：40例患者中3例肝脏T2*值处于正常水平，37例表现为不同程度沉铁状态，发病率为92.50%；26例患者的心脏T2*值处于正常水平，14例表现为不同程度的沉铁状态，发病率为35.00%。由此可知重型β地中海贫血以肝脏沉铁最为明显（ 字2=3.921，P0.05）。3例6岁受检者的左室射血分数超过65.0%，其余基本正常，由此可知铁沉积最早发生在6岁左右。结论：重型β地中海贫血患者体内铁的沉积出现越早，越容易造成重要脏器损害，而且铁过载越严重，铁过载发病率越高。 　　【关键词】 重型β地中海贫血； 沉铁状态； 铁过载发病率； ?F过载严重程度 　　【Abstract】 Objective：To evaluate the iron deposition status and the relationship between incidence of iron overload and the severity of iron overload in patients with severe β mediterranean anemia by magnetic resonance imaging （MRI）.Method：40 cases with severe β mediterranean anemia were selected as the study objects，the objects’ heart and liver T2* value were assessed by MRI，the left ventricular ejection fraction was analyzed by Agus software.Result：Iron deposition status in β mediterranean anemia：in 40 patients，3 cases with liver T2* value at the normal level，37 cases showed different degrees of iron deposition status，the incidence rate was 92.50%；26 cases with cardiac T2* value at the normal level，14 cases showed different degrees of iron precipitation，incidence rate was 35.00%.So it can be seen that the liver iron deposition was main in severe patients with β-mediterranean anemia （ 字2=3.921，P0.05）.3 cases with the left ventricular ejection fraction of 6 years old was more than 65.0%，and the rest was basically normal.The result showed that iron deposition occurred at the age of about 6 years old.Conclusion：The earlier deposition of iron in the patients with severe beta thalassemia，the more likely it is to cause serious organ damage， and the more serious the iron overload，the higher the incidence of iron overload. 　　【Key words】 Heavy β mediterranean anemia； Iron deposition status； Iron overload incidence； Iron overload severity 　　First-author’s address：Shenzhen No.2 People’s Hospital，Shenzhen 518000，China