三种疗法对慢性乙型肝炎治疗疗效的探讨.docVIP

三种疗法对慢性乙型肝炎治疗疗效的探讨 　　[摘要] 目的 探究3种不同治疗方法对慢性乙型肝炎的临床疗效。方法 所有乙肝患者均为福建省安溪县医院2013年5月―2016年1月间接收治，随机分组，Ⅰ组潘生丁、卡介苗治疗，Ⅱ组乙肝疫苗、猪苓多糖治疗，Ⅲ组恩替卡韦治疗，每组32例，6个月后观察3组治疗效果并进行比较。结果 ALT复常率比较，Ⅰ组为56.25%；Ⅱ组为65.62%；Ⅲ组为62.50%（P0.05）；HBVDNA转阴率比较，Ⅰ组为62.50%；Ⅱ组为46.87%；Ⅲ组为59.37%（P0.05）。3组不良反应发生率均为3.12%（P0.05）。结论 采用联合潘生丁和卡介苗、乙肝疫苗和猪苓多糖、单独恩替卡韦治疗乙肝均能够取得一定的临床疗效，临床中可以根据患者实际情况进行考虑选择适当的治疗方法，以期提高患者的临床治疗效果。 　　[关键词] 慢性；乙型肝炎；临床疗效 　　[中图分类号] R512 [文献标识码] A [文章编号] 1674-0742（2017）01（c）-0097-03 　　Study on Curative Effect of Three Kinds of Treatment Methods of Chronic Hepatitis B 　　CHEN Qiao-bin1， CHEN Jing-xiang1， LIN Zhen-de1， LIAO Jin-yu2 　　1.Department of Infection Disease， Anxi Hospital， Anxi， Fujian Province， 362400 China；2.Operation Room， Anxi Hospital of Traditional Chinese Medicine， Anxi， Fujian Province， 362400 China 　　[Abstract] Objective To study the clinical curative effect of three kinds of treatment methods of chronic hepatitis B. Methods 64 cases of patients were admitted and treated from May 2013 to January 2016 in Anxi Hospital，Fujian Province and divided into two groups， the groupⅠwere treated with dipyridamole and calmettes vaccine， the group Ⅱ were treated with hepatitis B vaccine and polyporus umbellatus polysaccharose， and the group Ⅲ were treated with entecavir， 32 cases were in each group， and the treatment effect was observed and compared after 6 months. Results The recovery rate of ALT was respectively 56.25%， 65.62% and 62.50% in the group Ⅰ， Ⅱ and Ⅲ（P0.05）， and the HBVDNA seroconversion rate was respectively 62.50%， 46.87% and 59.37% in the group Ⅰ， Ⅱ and Ⅲ， and the incidence rate of adverse reactions in the three groups was 3.12%（P0.05）. Conclusion Dipyridamole combined with calmettes vaccine， hepatitis B vaccine and grifola polysaccharide and single entecavir in treatment of hepatitis B can obtain a certain clinical curative effect， and we should consider the proper treatment method according to the practical conditions of patients in clinic in order to improve the clinical trea