不同剂量乌司他丁对心肺复苏后患者临床疗效的研究.docVIP

不同剂量乌司他丁对心肺复苏后患者临床疗效的研究 　　[摘要] 目的 探讨研究使用不同剂量的乌司他丁，对于心肺复苏后患者的治疗效果。 方法 整群选取该院在2013年6月―2014年5月期间所收治的心肺复苏后患者共计106例，以上患者全部为心脏骤停后经心肺复苏后自我循环康复，并且均是能够生存超过72 h的患者。按照随机原则分成实验组与对照组各为53例。两组患者全部进行普通心肺复苏抢救，使用普通心肺复苏常用的急救药物；在心肺复苏自我循环康复后；实验组患者使用乌司他丁剂量为40万U/次，2次/d。对照组患者使用乌司他丁，剂量20万U/次，2次/d。然后观察所有患者多器官功能衰竭产生情况；并统计对比两组患者在治疗28 d之后的生存状况。 结果 经治疗以后，观察组患者中多器官功能衰竭的发生率为33.3%（18/53）；明显低于对照组患者（58.5%，31/53）；该两组患者的多器官功能衰竭发生率对比，其差异具有统计学意义（χ2=8.374，P0.05）；治疗28 d后，观察组患者的生存率为73.6%；明显高于对照组（37.7%，20/53），该两组患者在治疗28 d以后的生存率对比；差异有统计学意义（χ2=9.115，P0.05）。 结论 使用乌司他丁能够帮助提高心肺复苏后患者的生存率；并且使用超剂量乌司他丁的临床治疗效果比较小剂量要好，值得该院学习与应用。 　　[关键词] 乌司他丁；不同剂量；临床 　　[中图分类号] R459.7 [文献标识码] A [文章编号] 1674-0742（2016）02（b）-0010-03 　　[Abstract] Objective To investigate the effect of different doses of ulinastatin on the outcome in patients after cardiopulmonary resuscitation. Methods A total of 106 cases who had sudden cardiac arrest but recovered self-circulation and survived longer than 72 hours after undergoing cardiopulmonary resuscitation with the conventional first aid medicine in our hospital from June 2013 to May 2014 were selected and randomly divided into the experimental group and the control group with 53 cases in each. After the recovery of self-circulation， the patients in the experimental group were given ulinastatin 400000 U， twice a day. And those in the control group were given ulinastatin 200000 U， twice a day. The incidence of multiple organ failure was observed in all the patients. And the survival status of the two groups was compared statistically after 28 days of treatment. Results After treatment， the incidence of multiple organ failure was much lower in the observation group than that in the control group [33.3%（18/53） vs 58.5%（31/53）] with statistically significant difference（χ2=8.374， P0.05）. The outcome of 28 days of treatment showed that the survival rate was much higher in the observation group than that in the control group [73.6% vs 37.7%（20/53）] with statistically significant difference（χ2=9.115， P0.0