抗结核药致药物性肝损伤危险因素Logistic回归分析.PDFVIP

抗结核药致药物性肝损伤危险因素的Logistic 回归分析 1＊ 2 1 何 涛 ，汪 峰 ，唐 武 （1.遂宁市船山区疾病预防控制中心，四川遂宁 629000；2.遂宁市中医院，四川遂 宁 629000） 中图分类号 R978；R969.3 文献标志码 A 文章编号 1001-0408（2016）12-1626-03 DOI 10.6039/j.issn. 1001-0408.2016.12.15 摘 要 目的：探讨抗结核药致药物性肝损伤的危险因素，为药物性肝损伤的防治提供科学依据。方法：采用回顾性分析的方法， 调查410例抗结核药治疗病例，并采用单因素和多因素Logistic 回归分析方法分析抗结核药治疗中可能诱发药物性肝损伤的危险 因素。结果：单因素回归分析提示性别、肝病史、饮酒史、营养不良与发生药物性肝损伤具有相关性；多因素回归分析显示，女性 （OR ＝2.320，P ＝0.021）、有肝病史（OR ＝4.332，P ＝0.006）、有饮酒史（OR ＝4.512，P ＝0.003）、有营养不良（OR ＝3.202，P ＝0.015） 为抗结核药致药物性肝损伤的危险因素，危险程度为有饮酒史＞有肝病史＞有营养不良＞女性。结论：女性、有肝病史、有饮酒 史、有营养不良患者使用抗结核药致药物性肝损伤的风险更高，基于相关危险因素的药物性肝损伤预防有助于改善患者的临床症 状，减少不良反应发生。 关键词 抗结核药物；药物性肝损伤；危险因素；Logistic 回归分析 Logistic Regression Analysis of Risk Factors of Antituberculosis Drug-induced Liver Injury 1 2 1 HE Tao ，WANG Feng ，TANG Wu （1.Center for Disease Control and Prevention in Suining Chuanshan District ， Sichuan Suining 629000，China ；2.Suining Municipal Hospital of TCM ，Sichuan Suining 629000，China ） ABSTRACT OBJECTIVE ：To explore the risk factors of antituberculosis drug-induced liver injury ，and provide scientific basis for the prevention and treatment of drug-induced liver injury. METHODS ：Retrospective analysis was adopted to investigate 410pa- tients with antituberculosis treatment ，single factor and multi-factor Logistic regression analysis were adopted to analyze the risk fac- tor that may induce liver injury in antituberculosis treatment. RESULTS ：Single factor regression analysis showed that gender ，hepa- titis history and drinking history were associated with drug-induced liver injury ，multi-factor regression analysis showed that female （OR ＝2.320，P ＝0.021），hepatitis history （OR ＝4.332，P ＝0.006），drinking history （OR ＝4.512，P ＝0.003）and malnutrition （OR ＝ 3.202，P ＝0.015）were risk factors of antituberculosis drug-induced liver injury ，and the degree of danger was drinking