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6 ·综述· 《中国肝脏病杂志(电子版)》2018年第10卷第2期
Adropin在非酒精性脂肪性肝病中的
研究进展
1 2 3 2 1,2,4 1,2,4 1.
刘群, 陈莎莎, 刘守胜, 杜水仙, 辛永宁 , 宣世英 (青岛大学医学院附属青岛市市立医院,山东 青
266011 2. 266011 3.
岛 ; 青岛市市立医院 感染科,山东 青岛 ; 青岛市市立医院 中心实验室,山东 青岛
266011 4. 266011
; 青岛市市立医院 消化内二科,山东 青岛 )
摘要:非酒精性脂肪性肝病(non-alcoholic fatty liver disease ,NAFLD )是指除外酒精或其他明确损害
因素所致的以肝细胞内脂肪过度沉积为主要特征的临床病理综合征,其发生发展与胰岛素抵抗、肥胖
和脂质沉积等密切相关。Adropin是近年来新发现的一种蛋白质,因具有调节脂质代谢和维持胰岛素
敏感性的重要作用已引起国内外的重视。本文就adropin 的功能及近年来adropin与NAFLD 的研究现状
进行综述,为增强NAFLD及其并发症的防治效果提供新思路。
关键词:脂肪肝,非酒精性 ;Adropin ;胰岛素抵抗;肥胖;脂质代谢
Research progress on adropin in non-alcoholic fatty liver disease
1 2 4 2 1,2,3 1,2,3
LIU Qun , CHEN Sha-sha , LIU Shou-sheng , DU Shui-xian , XIN Yong-ning , XUAN Shi-ying
(1.Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266011, Shandong
Province, China; 2.Department of Infectious Diseases, Qingdao Municipal Hospital, Qingdao 266011,
Shandong Province, China; 3.Central Laboratories, Qingdao Municipal Hospital, Qingdao 266011,
Shandong Province, China; 4.Department of Gastroenterology , Qingdao Municipal Hospital, Qingdao
266011, Shandong Province, China)
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by excessive
lipid deposition of hepatic cells, which is not caused by alcohol or other specific injury factors. Insulin
resistance, obesity, and lipid deposition are closely related to the occurrence and development of NAFLD.
Adropin, a newly discovered protein in recent years, plays an important role in regulating lipid metabolism
and maintaining insulin sensitivity. In this review, we summarized the function of adropi
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