合理的应用胺碘酮治疗老年室性心律失常66例疗效及安全性分析.docVIP

合理的应用胺碘酮治疗老年室性心律失常66例疗效及安全性分析 　　[摘要] 目的：观察合理应用胺碘酮在治疗老年室性心律失常中的疗效及安全性分析。方法：66例老年室性心律失常患者经合理给予胺碘酮治疗4周后观察其疗效及安全性分析。结果：治疗组患者住院期间及随访18个月后无死亡。住院期间及随访24个月后，治疗组抗心律失常治疗有效率为94.2%，对照组为53.1%（P＜0.01）。结论：合理应用胺碘酮治疗老年室性心律失常副作用少，安全有效。 　　[关键词] 老年人；室性心律失常；胺碘酮；合理用药 　　[中图分类号] R541.7[文献标识码]B [文章编号]1673-7210（2011）04（b）-154-02 　　 　　Reasonable application of amiodarone treatment of senile ventricular arrhythmia 66 cases effectiveness and safety analysis 　　WANG Yanou1, XU Kai2, ZHAO Bin3, ZHENG Haining4 　　1. Department of Cardiac Internal Medicine, Tianjin First Central Hospital, Tianjin 300192, China; 2. The Sports Center Hospital of Tianjin Nankai District, Tianjin 300381, China; 3. Clinical Medicine Department of Graduate School of Tianjin Medical University, Tianjin 300070, China; 4. Xiangyang Hospital of Tianjin Nankai District, Tianjin 300111, China 　　[Abstract] Objective: To observe reasonable application of amiodarone in the treatment of senile ventricular arrhythmia effectiveness and safety analysis. Methods: 66 cases with ventricular arrhythmia by giving reasonable amiodarone treatment after four weeks were observed the efficacy and safety analysis. Results: During hospitalization and after follow-up 18 months, no patients of treatment groupdied. During hospitalization and after follow-up 24 months, effective rate of treatment group after antiarrhythmic treatment was 94.2%, that of control group was 53.1% (P0.01). Conclusion: Reasonable application of amiodarone treatment of senile ventricular arrhythmia is with few side-effects, safe and effective. 　　[Key words] The elderly; Ventricular arrhythmia; Amiodarone; Rational drug use 　　 　　胺碘酮（商品名：可达龙）为Ⅲ类抗心律失常药物，对恶性心律失常有较好疗效，如无禁忌证是治疗室性心律失常患者的首选药物。近年来完成的一些前瞻性的随机、双盲、安慰剂对照的大规模临床实验，为胺碘酮抗心律失常的有效性和安全性提供了可靠的临床依据[1]，目前已证实胺碘酮可降低心律失常患者的病死率（特别是对难治性心律失常患者）。为进一步研究合理应用胺碘酮治疗老年室性心律失常中的作用，笔者对130例老年室性心律失常患者给予胺碘酮进行疗效观察及安全性分析。 　　1 资料与方法 　　1.1 一般资料 　　2007年9月～2010年9月，笔者经治本院老年室性心律失常患者130例。全部患者均经心电图确诊，临床诊断标准符合文献[2]。年龄60～79岁，平均（63.3±2.5）岁。患者均有不同程度