十味龙胆花胶囊联合西药治疗慢性阻塞性肺疾病急性加重临床的研究.docVIP

十味龙胆花胶囊联合西药治疗慢性阻塞性肺疾病急性加重临床的研究 　　摘要：目的 观察十味龙胆花胶囊联合西药治疗轻度慢性阻塞性肺疾病急性加重（痰热壅肺证）患者的临床疗效。方法 选择符合轻度慢性阻塞性肺疾病急性加重的西医诊断标准且中医辨证为痰热壅肺证患者192例，随机分为观察组和对照组各96例。观察组应用十味龙胆花胶囊及西药常规治疗，对照组应用西药常规治疗，疗程10 d，测定并比较治疗前后中医证候积分、主要症状评分和肺功能变化。结果 疗程结束后，观察组14例失访，对照组15例失访。观察组总有效率为80.29%（66/82），对照组为56.79%（46/81），观察组优于对照组（Plt;0.05）;观察组改善患者咳嗽严重程度、频率、咯痰量的疗效优于对照组（Plt;0.05）;2组患者在喘息症状、肺功能方面均有改善，疗效相当。结论 十味龙胆花胶囊联合西药常规治疗轻度慢性阻塞性肺疾病急性加重（痰热壅肺证）患者的疗效及在改善咳嗽、咯痰等临床症状方面优于单纯西药常规治疗。 　　关键词：慢性阻塞性肺疾病;急性加重;十味龙胆花胶囊;痰热壅肺证;临床研究 　　DOI：10.3969/j.issn.1005-5304.2015.02.005 　　中图分类号：R259.639文献标识码：A 文章编号：1005-5304（2015）02-0013-04 　　Clinical Study on Shiwei Longdanhua Capsule Combined with Western Medicine for Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease ZHANG Wen-jiang，FAN Chang-zheng， GAO Jin-zhu， WANG Bing， ZHENG Jing-tie （Department of Pulmonary Diseases， Xiyuan Hospital of China Academy of Chinese Medical Sciences， Beijing 100091， China） 　　Abstract：Objective To observe the clinical efficacy of Shiwei Longdanhua Capsule combined with western medicine on patients with mild acute exacerbation of chronic obstructive pulmonary disease （COPD） with phlegm-heat obstructing lung syndrome. MethodsTotally 192 cases of COPD with mild acute exacerbation （phlegm-heat obstructing lung syndrome） were recruited. They were randomly divided into the treatment group （96 cases） and the control group （96 cases）. Patients in the control group were treated in line with the regular Western treatment， while patients in the treatment group were additionally treated by Shiwei Longdanhua Capsule. After 10-day treatment， the changes of TCM syndrome score， symptom integral and the lung function before and after treatment were compared. Results After treatment， 14 patients withdrew from the treatment group and 15 patients withdrew from the control group. The total efficiency rate of TCM syndrome was 80.49% （66/82） in the treatment group， while it was 56.79% （46/81） in the control group， with statistical difference b