地龙降压胶囊联合西医常规治疗肝阳上亢型原发性高血压伴亚临床动脉硬化临床的研究.docVIP

地龙降压胶囊联合西医常规治疗肝阳上亢型原发性高血压伴亚临床动脉硬化临床的研究 　　摘要：目的 探?地龙降压胶囊联合常规西药治疗对肝阳上亢型原发性高血压伴亚临床动脉硬化患者的降压作用及对动脉硬化的改善情况。方法 采用随机数字表法将120例肝阳上亢型原发性高血压伴亚临床动脉硬化患者分为治疗组和对照组各60例。对照组遵循个体化、小剂量、长效、联合的原则予常规降压治疗。治疗组在对照组基础上予地龙降压胶囊，每次1粒，每日2次，晨起及睡前口服。均连续治疗6周。观察2组治疗前及治疗2、4、6周血压、颈动脉内膜中层厚度（IMT）、脉搏波传导速度（PWV）和踝臂指数（ABI），评价临床疗效。结果 治疗组、对照组分别脱落2、3例。治疗组总有效率为91.38%（53/58），对照组为82.46%（47/57），治疗组明显优于对照组，差异有统计学意义（P0.05）。与本组治疗前比较，2组治疗后血压水平明显降低（P0.05）；治疗组治疗后明显低于对照组（P0.05）。与本组治疗前比较，治疗2、4周2组IMT、PWV明显下降，治疗2、4、6周ABI明显下降，差异有统计学意义（P0.05）。2组治疗4周IMT、PWV比较差异有统计学意义（P0.05）；2组治疗2、4周ABI比较差异有统计学意义（P0.05）；2组治疗6周IMT、PWV、ABI比较差异有统计学意义（P0.05）。结论 地龙降压胶囊联合常规西药治疗原发性高血压伴亚临床动脉硬化可增强降压效果，在一定程度上改善IMT、PWV、ABI。 　　关键词：原发性高血压；地龙降压胶囊；颈动脉内膜中层厚度；脉搏波传导速度；踝臂指数 　　DOI：10.3969/j.issn.1005-5304.2018.04.006 　　中图分类号：R259.441 文献标识码：A 文章编号：1005-5304（2018）04-0024-04 　　Abstract： Objective To investigate the synergistic antihypertensive effect of Dilong Jiangya Capsules on patients with essential hypertension with subclinical atherosclerosis of liver yang hyperactivity type and its effect on arteriosclerosis. Methods Totally 120 patients with essential hypertension with subclinical atherosclerosis were randomly divided into treatment group （60 cases） and control group （60 cases）. Control group received antihypertensive treatment by following the individual， low-dose， long-term， combined principle， while treatment group was given Dilong Jiangya Capsules on the basis of control group， one capsule per time， twice a day， orally taken during early morning and bedtime. The treatment for both groups lasted for six weeks. Blood pressure， carotid artery intima-media thickness （IMT）， pulse wave velocity （PWV） and ankle-brachial index （ABI） were observed before and 2， 4 and 6 weeks after treatment. Blood pressure clinical efficacy was evaluated. Results Two and three cases were lost in the treatment group and control group， respectively. The total effective rate was 91.38% （53/58） in the treatment group and 82.46% （47/57） in the control group， and the treatment gro