对苯二胺染发剂与肾损害的相关性研究进展-海南医学.PDFVIP

Hainan Med J, Jul. 2016, Vol. 27, No. 14 海南医学2016年7月第27卷第14期 doi:10.3969/j.issn.1003-6350.2016.14.030 ·综 述· 对苯二胺染发剂与肾损害的相关性研究进展 梁家瑞，蒋红樱，白彝华，张乐航 ( 昆明医科大学附属第二医院肾脏内科，云南 昆明 650101) 【摘要】 对苯二胺(PPD)是氧化型染发剂中一种重要的成分，随着PPD 染发剂的大规模生产及使用，PPD 的 引起的肾损害不断引起关注。PPD 可以通过消化道或皮肤接触进入人体内。苏丹、印度等国报道了大量口服PPD 染发剂引起急性肾损伤的病例，且大部分需要肾脏替代治疗。然而通过皮肤进入人体的PPD 量较少并经过皮肤及 角质细胞乙酰化解毒，因此导致肾损害的报道较罕见，很多研究仍在努力寻找长期皮肤接触PPD 与慢性肾损害之 间的关联。本文对PPD 染发剂和肾损害的相关性研究给予综述。 【关键词】 染发剂；对苯二胺；1,4-二氨基苯；肾损伤；肾疾病 【中图分类号】 R692 【文献标识码】A 【文章编号】 1003—6350（2016 ）14—2325—04 Correlationofp-Phenylenediamine-containinghairdyewithkidneyinjury.LIANGJia-rui,JIANGHong-ying,BAI Yi-hua,ZHANGYue-hang.DepartmentofNephrology,theSecondAffiliatedHospitalofKummingMedicalUniversity, Kumming650101,Yunnan,CHINA 【Abstract】 p-Phenylenediamine (PPD) is one of the most important ingredients in oxidative hair dyes. Kidney diseases induced by PPD have caused increasing concern because of the mass manufacture and application of PPD-con- taining hair dye. PPD can be absorbed into human body through digestive tract or skin. Sudan and India reported a lot of cases of acute kidney injury (AKI) induced by oral intake of PPD, most of which require renal replacement treatment. However, only a small quantity of PPD is absorbed through skin, and the absorbed PPD is detoxicated by N-Acetylation in skin and keratinocytes. Consequently, the related reports of kidney injury through skin are very rare. Still, lots of re- searches have been conducted to find the correlation between long-term exposure to PPD-containing hair dye and chron- ic kidney injury. In this paper, the studies of PPD-induced kidney injuries are summarized.