综述·中药药效物质基础主要研究方法概述-天津中草药杂志社.PDF

中草药 Chinese Traditional and Herbal Drugs 第 49 卷 第 4 期 2018 年 2 月 ·941 · ·综 述 · 中药药效物质基础主要研究方法概述 1 2* 1 1 3 2 1 汪小莉 ，刘 晓 ，韩燕全 ，汪永忠 ，周珊珊 ，蔡宝昌 ，周 导 1. 安徽中医药大学第一附属医院，国家中医药管理局中药制剂三级实验室，安徽 合肥 230031 2. 南京中医药大学，江苏 南京 210023 3. 安徽省胸科医院，安徽 合肥 230031 摘 要：研究中药药效物质基础对于阐明中药作用机制和提高中药质量标准具有关键的作用，中药药效物质基础研究方法主 要包括：血清药物化学、谱效相关和药动学-药效学（PK-PD ）模型研究等方面。通过查阅相关文献，对中药药效物质基础 的主要研究方法进行综述，为阐明中药复方的药效物质基础提供参考。 关键词：中药复方；药效物质基础；血清药物化学；谱效相关；PK-PD 模型 中图分类号：R284 ；R285 文献标志码：A 文章编号：0253 - 2670(2018)04 - 0941 - 07 DOI: 10.7501/j.issn.0253-2670.2018.04.030 Overview on main research method of effective material basis of Chinese materia medica 1 2 1 1 3 2 WANG Xiao-li , LIU Xiao , HAN Yan-quan , WANG Yong-zhong , ZHOU Shan-shan , CAI Bao-chang , 1 ZHOU Dao 1. Grade 3 Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China 2. Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China 3. Anhui Chest Hospital, Hefei 230031, China Abstract: Studies on the effective material basis of Chinese materia medica (CMM), which is critical for clarifying the mechanism of action and control quality. The main research methods on the effective material basis of CMM were reviewed through consulting relevant literature in this paper. It mainly includes the serum pharmaceutical chemistry, spectrum-effect and PK/PD model research. Key words: Chinese materia medica formula; effective material basis; serum pharmacochemistry; spectrum-effe