基于综合性meta分析的乳三肽v_省略_对照实验中的抗高血压效能_英文_光翠娥.pdf

212 2015, Vol.36, No.17 食品科学 ※营养卫生 Antihypertensive Effect of Lactotripeptides VPP and IPP in Randomized Placebo-Controlled Trials: A Comprehensive Meta-Analysis 1 1 1 2 3 1 GUANG Cuie , SHANG Jiangang , JIANG Bo , Franco MILANI , Robert Dick PHILLIPS , ZHANG Hailing (1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; 2. Department of Food Science, University of Wisconsin-Madison, Madison 53706-1565, USA; 3. Department of Food Science and Technology, University of Georgia, Griffin 30223-1797, USA) Abstract: - - A comprehensive meta-analysis was conducted to evaluate the effect of lactotripeptides (LTPs) Val Pro Pro - - (VPP) and Ile Pro Pro (IPP) on blood pressure (BP) after oral administration. Twenty one randomized, placebo-controlled studies with 27 trials consisting of 2 142 prehypertensive or hypertensive individuals were identified through a defined search strategy, and due to heterogeneity among studies the random effect model was used for the analysis. The pool effect was a reduction of －1.78 mmHg [95% confidence interval (CI): －2.47 to －1.08, P 0.001] for systolic blood pressure (SBP) and －0.67 mmHg (95% CI: －1.11 to －0.23, P 0.001) for diastolic blood pressure (DBP), and no publication bias was present. Subgroup analyses showed that the intake of LTPs resulted in significant decreases in BP in Asians (SBP: －6.56 mmHg; DBP: －3.01 mmHg), in subjects from publications before 2008 (SBP: －6.57 mmHg, DBP: －3.08 mmHg) and participants with a dose of less than 5 mg/d (SBP: －5.20 mmHg;