多项生化指标对高龄老年急性冠脉综合征早期诊断、危险分层及预后评估价值的初步研究-老年心血管科专业论文.docxVIP

The preliminary study of the value of markers in early diagnosis, risk stratification and prognosis assessment of the very elderly with acute coronary syndrome Postgraduate: Zhou Yun Supervisor:Prof. Liu Feng Department of Geriatric, Guangzhou First Municipal People’s Hospital Affiliated to Guangzhou Medical College Abstract [Background] Acute coronary syndrome(ACS) is an acute coronary heart disease. It is mainly caused by acute myocardial ischemia and infarction based on coronary atherosclerosis plaque rupture, platelet congestion and thrombosis. It has high incidence and high fatality rate. In the developed countries, the proportion of people of age above 60 years old accounted for 20%, and predicted to reach to 32% in 2050.Accordingly,the incidence of acute coronary syndrome in elderly people is raised correspondingly. With the rapid development of economy and the lifestyle changing, China started to become an aging society. With the risk factors of angiocardiopathy increased, such as hypertension and diabetes. ACS-related morbidity has gradually been rising in China. Acute coronary syndrome has been the major cause of death in elderly patients.ACS includes a group of diseases are different in the clinical characteristics, risk and prognosis. Elderly and very elderly patients with ACS have a high risk of death and adverse outcome because of abnormal symptoms and mutiple complications. The steps of diagnosis included analyzing the risk factors for the elderly patients, and then giving the appropriate risk stratification to them to make proper therapeutic decision and monitor prognosis. At present, lots of studies came from abroad; domestic experiments have suggested that inflammatory reaction, platelet activation, functional disorder of endothelial cell and necrosis of cardiac muscle cell commonly participate the processes of the occurrence and progression of ACS. Many mediators of inflammation and markers of myocardial damage were released into blood