细胞激活与增殖炎症性介质产生前炎症性细胞因子分泌金属蛋白酶及k_xsvpnm.pptVIP

3、对II型胶原型关节炎 (CIA)的影响 ? All Rights Reserved to Zhou Hua/HKBU* Prepare rats and load CII/IFA into a syringe Intradermally injection of collagen II on day 0 and 7 Arthritic signs appeared around day 10-15 Prepare CII/IFA emulsion Zhou H. BBRC;376(2):352-357. ? All Rights Reserved to Zhou Hua/HKBU* Fig. 1. Inhibition of the incidences (A), arthritic scores (B), hind paw volumes (C), and ESR (D) of CIA rats by treatment with sinomenine. Rats were treated daily either with an i.p. injection of 25, 50 or 100 mg/kg sinomenine or vehicle, or with an oral dose of 1 mg/kg indomethac