依达拉奉对帕金森病的疗效观察.docVIP

依达拉奉对帕金森病的疗效观察 ［ ］目的研宄依达拉奉治疗早、晚期帕金森 病（PD）的临床效果。方法选择2015年4月?2016 年4月在我院治疗的36例PD患者，将患者按病程分 为早期PD组（彡3.5年）和晚期PD组（彡4年）。在 常规PD治疗的基础上，给予依达拉奉30 mg，加入 250 ml 0.9%氯化钠溶液中静脉滴注，2次/d，连续应 用2周。应用PD统一评分量表（UPDRS）评价治疗效 果，并观察不良反应发生情况，同时检测与比较两组 治疗前后的血清AM-42、BDNFo结果治疗后，早期 PD组在日常生活活动，精神活动、行为和精神，运动 检查三个方面的UPDRS评分均较治疗前显著降低 （P0.05）。早期PD组治疗后的血清A 0 1-42、BDNF 则高于晚期PD组（P ［关键词］依达拉奉；帕金森病；疗效 ［ ］R742.5 ［ ］A ［ ］ 1674-4721 (2016) 12 (a) -0130-03 Curative effect observation of Edaravone in Parkinson disease WANG Su Department of the First Internal Medicine, General Hospital of Armed Police Frontier Forces in Shenzhen City of Guangdong Province, Shenzhen 518029，China [Abstract]Objective To study the clinical effect of Edaravone treating Parkinson disease (PD) of early and late stage.Methods 36 patients with treated by our hospital from April 2015 to April 2016 were selected， and they were divided into PD of early stage group ( 3.5 years) and PD of late stage group ( ^4 years) .Patients were treated by Edaravone of 30 mg added into 250 ml of 0.9% sodium chloride solution to intravenously drip for 2 times every day on the basis of the routine PD treatment，and drugs were used for 2 weeks.The unified rating scale of PD (UPDRS) was used to evaluate the curative effect after treatment，incidence of complications was observed，and serum A 3 1-42 and BDNF between two groups before and after treatment were detected and compared.Results After treatment, mental activity, behavior and mind，daily living activity and motor examination of the UPDRS score in PD of early stage group were significantly decreased compared with before treatment (P0.05) .The serum A 3 1-42 and BDNF of PD of early stage group after treatment were higher than those of PD of late stage group （P 1 资料与方法 1.1 一般资料 选择2015年4月?2016年4月在我院就诊的PD 患者36例，按病程分为早期PD组（$3.5年）和晚 期PD组（彡4年）。早期PD组20例，其中男12例， 女8例；年龄56?76岁，平均（63.5±6.5）岁；平 均病程（1.8±1.1）年；PD症状严重程度H-Y分级为 1?2级。晚期PD组16例，其中男8例，女8例；年 龄57?78岁，平均（65.5±5.5）岁；平均病程（5.8 ±3.8）年；PD症状严重程度H-Y分级为4?5级。两 组患者在年龄、性别等方面比较差异