可重复使用之固体酸在药物合成与生质能的催化应用摘要Abstract.PDF

可重複使用之固體酸在藥物合成與生質能的催化應用 研究者 ：沈玉宣 指導者 ：鄭淑芬教授 許名智老師 摘要 生質能源是最佳的能源之一，而固體酸觸媒最能符合綠色化學，因此本研究要 開發一種可以水解纖維素得到生質能的固體酸觸媒。 將芳香族 X 與 3-氯丙基三甲氧基矽烷反應，產物嫁接至中孔洞 SBA-15-p 上， 再進行磺酸化，得到固體酸 TPS-SBA-15-p ，將其應用在催化酯化反應及阿斯匹靈的 合成，催化效果優於已發表的固體酸觸媒。 將 TPS-SBA-15-p 應用在催化水解纖維素，2 g 纖維素與 0.5 g 觸媒在不鏽鋼高壓 反應鍋中加熱至 150°C 反應 7 天，轉化率達 75.7％，主產物為乙醯丙酸及癸烷，兩 者碳數佔全部產物碳數的 64％，乙醯丙酸的用途很廣，而癸烷是汽柴油的成分。 另外，TPS-SBA-15-p 具有兩種催化活性位置，此兩種催化活性官能基具有協同 催化作用，因此很容易催化水解二噁烷(dioxane)及苯甲醚，也就具有催化水解纖維 素的能力。 Abstract The production of biomass energy is of significant global importance for both the reduction of environmental impact and the conservation of finite energy resources. Therefore, advanced acid catalysts with excellent acid capacity and the ability to hydrolysis cellulose need to be developed to protect both our environment and our energy resources. In this report TPS-SBA-15-p was first used in the esterification, which is the reaction before the production of biofuel; and the salicylic acid acylation reaction, which is a typical pharmaceutical preparation, both of them demonstrated excellent yield and high quality. Later, TPS-SBA-15-p was also used in the hydrolysis of cellulose. 2g of cellulose with 0.5g of catalyst were added and then heated under static condition at 150°C for 7 days. The conversion was up to 75.7％, while the main products were levulinic acid and decane, which took up 64％ of the C content. On the other hand, TPS-SBA-15-p owns two catalytic active site, which certify that our new catalyst have a synergistic effect between nuclarfy and acid, could hydrolyze dioxane and anisole, and also promote the hydrolyzation of cellulose