卵黄抗体的结构与功能其在人及动物疾病中应用进展..docVIP

卵黄抗体的结构与功能其在人及动物疾 病中应用进展 余运运孙丽娜孙万邦 遵义医学院珠海校区/贵州省免疫学研宄生教育创新 基地 鸡卵黄免疫球蛋白(IgY) 乂称卵黄抗体，是禽类受特定抗原刺激后分泌的特异 性抗体。因異有耐热、耐酸和抗蛋白酶降解等特性，早期开发产品作为食品或食 品添加剂应用受到重视，其产品开发在食品安全、生态农业方面奋重要社会效益 和经济效益，产品由于含针对某病原生物特异性抗体，可抵抗病原生物的感染， 因而在动物及人类疾病的防治方而有开发应用价值，在人类健康保健也有十分 重耍的应用前景。本文就在动物和人类抗病毒、抗细菌、抗寄生虫、抗肿瘤等相 关的IgY生物制剂产品研发及应用进行综述。 关键词： 卵黄抗体;产品研发;疾病防治; 孙万邦，Email:sunwb7224@sina. con。 2017-06-14 基金：贵州省特色重点学科项B (ZDXK20147) Advances in structure, function and application of egg yolk antibody in human and animal diseases YU Yun-yun SUN Li-na SUN Wan-bang Zhuhai Campus of Zunyi Medical College/Education and Innovation Base for Immunology Graduate Students in Guizhou Province; Abstract： Egg yolk immunoglobulin (IgY) ， also called egg yolk antibody, is a specific antibody secreted by birds after stimulation with certain antigens. For that it exhibits good resistance to heat， acid and proteinase-mediated degradation, its early-stage products were developed as food or food additives, and they have gained great social and economic benefits in both food safety and ecological agriculture fields. Due to the specific antibodies contained in these products, the products can help to resist pathogen infection. Therefore egg yolk antibody shows great value for development and application in the prevention and treatment of animal and human diseases, and also shows great potential in human health care area. This review focuses on the development and applications of IgY biologies related with antiviral, antibacterial, anti parasi tic and antitumor activities. Keyword： egg yolk antibody; product development; prevention and treatment of diseases; Received： 2017-06-14 卵黄抗体(Immunoglobulin of egg yolk/egg yolk antibody, Ig Y)是指特定 抗原刺激禽类B淋巴细胞，由B细胞分化成浆细胞并由此分泌特异性抗体进入血 液循环，当血液流经卵巢时在卵细胞中逐渐蓄积，形成卵黄抗体。卵黄抗体具有 性质稳定、特异性强、制备成木低、U服安全等优点在家禽、家畜传染病的防治 中已得到广泛的应用。产品的开发也在生态农业和食品安全方面产生了良好的经 济效益和社会效益。在诊断、预防和治疗人类和动物各种疾病屮具有良好的应用 价值。lg Y的产品在动物疾病防治应用报道较多，在医学中产品研发与应用报 道较少，木文就Ig Y产品研发及应用进行综述。 1卵黄抗体结构功能及研发进展 1.1 Ig Y的分泌 禽类的免疫系统包括细胞和体液免疫系统，分别受法氏囊和胸腺