益气活血化痰养心汤辅助治疗不稳定型心绞痛临床的研究.docVIP

益气活血化痰养心汤辅助治疗不稳定型心绞痛临床的研究 　　摘要：目的 观察益气活血化痰养心汤治疗不稳定型心绞痛的临床疗效及安全性。方法 采用半随机法将165例患者分为观察组84例和对照组81例。2组均予常规治疗。观察组并予益气活血化痰养心汤，每日1剂，每日2次，口服。连续治疗4周，随访4周。观察2组治疗前后心绞痛分级、心电图疗效，检测全血黏度、纤维蛋白原、血清一氧化氮（NO）、超氧化物歧化酶（SOD）及血浆内皮素（ET）、血栓素B2（TXB2）、6-酮-前列腺素F1α（6-keto-PGF1α）水平，观察中医证候积分，评价不良反应与安全性。结果 与本组治疗前比较，2组心绞痛分级显著降低（P0.05）。与本组治疗前比较，2组全血黏度和血浆纤维蛋白原及ET、TXB2水平下降，NO、6-keto-PGF1α水平升高（P0.05），治疗及随访均未见肝、肾功能异常。结论 益气活血化痰养心汤能明显缓解不稳定型心绞痛症状，且可维持血管收缩功能及血小板聚集作用的平衡。 　　关键词：不稳定型心绞痛；益气活血化痰养心汤；临床研究 　　DOI：10.3969/j.issn.1005-5304.2018.01.004 　　中图分类号：R259.422 文献标识码：A 文章编号：1005-5304（2018）01-0015-04 　　Clinical Study on Yiqi Huoxue Huatan Yangxin Decoction for Treatment of Unstable Angina Pectoris 　　WU Juan1， CHENG Chou-fu2 　　1. School of Chinese Medicine， Hunan University of Chinese Medicine， Changsha 410208， China； 　　2. The First Hospital of Hunan University of Chinese Medicine， Changsha 410007， China 　　Abstract： Objective To observe the clinical efficacy and safety of Yiqi Huoxue Huatan Yangxin （IHHY） Decoction for treatment of unstable angina pectoris patients. Methods Totally 165 cases of patients with unstable angina pectoris were collected and divided into observation group （84 groups） and control group （81 patients） by semi-random method. Patients in both groups received western medical， and patients in observation group were added with IHHY Decoction， one dosage a day， twice a day， orally. The therapeutic course for both groups was 4 weeks， with 4 weeks follow up. Angina pectoris grade and ECG effect in both groups were observed. Blood viscosity， fibrinogen， serum NO， superoxide dismutase （SOD）， plasma levels of endothelin （ET）， thromboxane B2 （TXB2）， 6-keto-PGF1α， were measured， and TCM syndrome score was observed. The incidence of all adverse reactions was recorded. Results After treatment， the angina pectoris grade of both groups were lower than before， with statistical significance （P0.05）. Compared with before treatment， whole blood viscosity， plasma fibrinogen， levels of ET and TXB2 decre