祛风清热胃苓汤联合氯雷他定递减疗法治疗慢性荨麻疹临床的研究.docVIP

祛风清热胃苓汤联合氯雷他定递减疗法治疗慢性荨麻疹临床的研究 　　摘要：目的 观察祛风清热胃苓汤联合口服氯雷他定递减疗法治疗慢性荨麻疹（CU）的临床疗效。方法 将108例CU患者随机分为治疗组和对照组各54例，治疗组予祛风清热胃苓汤口服，同时服用氯雷他定10 mg，每日1次，并根据症状控制情况逐渐减量，对照组仅予氯雷他定递减疗法。2组均以2周为1个疗程，连续观察4个疗程。治疗8周后根据患者症状积分下降综合指数评价2组患者近期临床疗效，并于治疗4、6、8周时进行服用抗组胺药物评分。对痊愈患者停药后1、3、6个月进行随访，对比2组痊愈患者远期疗效。结果 8周后治疗组治愈27例，近期疗效有效率为96.15%，对照组分别为13例和65.38%，差异有统计学意义（P0.05）。治疗组服用抗组胺药物评分为（0.553±0.239）分，对照组为（0.721±0.245）分。治疗组远期临床疗效显著优于对照组。结论 祛风清热胃苓汤联合口服氯雷他定递减疗法治疗CU的近期及远期临床疗效均优于对照组。 　　关键词：慢性荨麻疹；祛风清热胃苓汤；氯雷他定；临床观察 　　DOI：10.3969/j.issn.1005-5304.2015.05.009 　　中图分类号：R275.982.4 文献标识码：A 文章编号：1005-5304（2015）05-0029-04 　　Abstract：Objective To observe the clinical efficacy of Qufeng Qingre Weiling Decoction combined with the decreasing amount of loratadine in treatment of chronic urticaria （CU）. Methods Totally 108 CU patients were randomly divided into treatment group and control group， 54 cases in each group. The treatment group was given Qufeng Qingre Weiling Decoction combined with the decreasing amount of loratadine （10 mg， 1 time per day） according to symptom controlling situation， and control group with the decreasing amount of loratadine only. Both groups were treated for 4 treatment courses （2 weeks as a treatment course）. Symptom score reduce index was used to calculate the effective rate after 8 weeks of treatment. And the taking antihistamine medicine score was recorded 4， 6， 8 weeks of treatment. The follow-up visits were made to observe long-term efficacy of the cured patients 1 month， 3 months and 6 months after discontinuing the medication. Results Totally 27 cases from the treatment group were cured， with a total short-term effective rate of 96.30%；13 cases from the control group were cured， with a total short-term effective rate of 65.38%， with statistical significance （P0.05）. The taking antihistamine medicine score in treatment group （0.553 ± 0.239） was lower than that in control group （0.721 ± 0.245）， namely the symptom improvement in treatment group was better than that in control group by