沙美特罗替卡松吸入剂对慢性阻塞性肺疾病Ⅲ~Ⅳ级的的疗效观察.docVIP

沙美特罗替卡松吸入剂对慢性阻塞性肺疾病Ⅲ~Ⅳ级的的疗效观察 　　[摘要] 目的 观察沙美特罗替卡松吸入剂对慢性阻塞性肺疾病（COPD）Ⅲ～Ⅳ级的疗效。 方法 将通过临床及肺通气功能检查明确诊断的84例COPD患者Ⅲ～Ⅳ级随机分为对照组和治疗组：对照组给予解痉、祛痰、家庭氧疗等常规治疗，治疗组在此基础上给予吸入沙美特罗替卡松吸入剂（50 μg/250 μg）1次1吸，每日2次，疗程为3个月。两组均按需吸入沙丁胺醇气雾剂。分别对两组患者治疗前后的临床症状及肺功能指标进行观察对比，评价药物短期疗效。 结果 治疗组和对照组临床总有效率比较，差异有统计学意义（P ＜ 0.05），肺通气功能检查FEV1占预计值治疗前（1.07±0.21）%，治疗后（1.38±0.18）%；第一秒用力呼气容积（FEV1）／用力肺活量（FVC），治疗前（44.45±7.14）%，治疗后（53.56±7.24）%，差异均有统计学意义（均P ＜ 0.05），而对照组各指标差异均无统计学意义。 结论 在COPD Ⅲ～Ⅳ级中应用沙美特罗替卡松吸入剂能提高患者肺功能，明显改善症状，提高活动耐力。 　　[关键词] 沙美特罗替卡松吸入剂；慢性阻塞性肺疾病；疗效观察 　　[中图分类号] R563.1 [文献标识码] A [文章编号] 1673-7210（2012）02（c）-0067-03 　　 　　Observation of curative effects on Salmeterol Fluticasone Inhalation in chronic obstructive pulmonary diseases of grade Ⅲ to Ⅳ 　　JING Weige1 YANG Jun1 YU Jianjun2 　　1.Department of Respiration, Chengde Central Hospital, Hebei Province, Chengde 067000, China; 2.Department of Urinary Surgery, 266th Hospital of Peoples Liberation Army, Hebei Province, Chengde 067000, China 　　[Abstract] Objective To observe the curative effects of Salmeterol Fluticasone Inhalation on chronic obstructive pulmonary diseases (COPD) of grade Ⅲ to Ⅳ. Methods 84 patients with COPD of grad Ⅲ to Ⅳ diagnosed by clinical and pulmonary ventilation function examinations were randomly divided into the control group and the treatment group: the control group was given spasmolysis, phlegm elimination, home oxygen therapy and other conventional treatment and the control group was given additional Salmeterol Fluticasone Inhalation (50 μg/250 μg) once per suction and twice per day for 3 months on this basis. Both groups of patients inhaled Salbutamol Aerosol on demand. The clinical symptoms and pulmonary function indicators before and after treatment of the two groups were observed and compared respectively, and the short-term curative effects were evaluated. Results The total effective rate of treatment group and control group was statistically significant (P ＜ 0.05), the pulmonary function test showed that FEV1 account