探讨温阳养心复律汤治疗阵发性房颤的疗效及对阵发性房颤患者血清超敏反应蛋白和血清..docVIP

探讨温阳养心复律汤治疗阵发性房颤的疗效及对阵发性房颤患者血清超敏C-反应蛋白和血清假性血友病因子水平的影响 刘爱琴王庆云 a雪 ［摘耍］目的：观察温阳养心复律汤对阵发性房颤患者血清超敏C-反应蛋白 (High-sensitivity C-reactive protein,hs-CRP)水平及血清假性血友病因子(Vascular Von Willebrand factor,vWF)水平的影响，探讨温阳养心复律汤治疗阵发性房颤的 作用机制及其有效性、安全性，促进临床应用。 方法：选取2009年1/3-2012年1月于我院住院的阵发性房颤患者178例，随 机分为2组：试验组(温阳养心复律汤组)97例，对照组(胺碘酮组)81例。 在治疗原发病及抗凝治疗基础上，对照组给予胺碘酮治疗，试验组给予温阳养心 复律汤治疗，疗程4周。分别于治疗后1周、2周、3周及4周检测两组患者的 血清hs-CRP及vWF浓度，并观察两组患者治疗后的复律情况、临床症状改善情 况及不良反应发生情况。 结果： hs-CRP及vWF浓度比较：治疗1周后、2周后、3周后、4周后试验组和对照组 的hs-CRP及vWF浓度治疗前均下降，治疗前后比较，差异有统计学意义 (Plt;0.05),而试验组较对照组下降更显著(Plt;0.05)o 两组患者治疗4周后复律情况比较:试验组转复窦性心律者71例，有效率73.20%, 对照组59例，有效率为72.84%，两组比较差异无统计学意义(Pgt;0.05)o ［关键词］温阳养心复律汤胺碘酮房颤阵发性 hs-CRP vWF临床症 状 The Efficacy of Wen Yang Yang Xin Fu Lv Decoction in Patients with Paroxysmal Atrial Fibrillation and Its Influence on Their Serum High-sensitivity C-reactive Protein and Serum von Willebrand Factor Liu Aiqin, Wang Qingyun, Lv Xue Abstract: Objective To Observe the influence of Wen Yang Yang Xin Fu Lv Tang on serum high-sensitivity C-reactive protein and serum von Willebrand factor levels and investigate its action mechanism, effectiveness, and safety in curing patients with paroxysmal atrial fibrillation. Methods: 178 cases of paroxysmal atrial fibrillation patients at the authorrsquo;s hospital from January 2009 to January 2012 were divide into 2 groups: 97 cases in test group (Wen Yang Yang Xin Fu Lv Tang group ) and 81 cases in control group (Amiodarone group). Based on the treatment of primary disease and anticoagulant therapy, the control group accepted Amiodarone therapy while the test group accepted Wen Yang Yang Xin Fu Lv Tang therapy. All the cases accept 4 weeks of treatment. The serum sh-CRP and vWF levels in patients after one week, two weeks, three weeks and four weeks of the treatment were studied. The cardioversion improvement of clinical symptoms, and adverse events of the two groups of patients after treatment were also recorded. Results 1.Compare the hs-CRP and vWF concentration： hs-C