联合降压治疗老年高血压的的疗效观察.docVIP

联合降压治疗老年高血压的的疗效观察 　　[摘要] 目的：探讨联合应用降压药治疗老年高血压的疗效。方法：采取随机、平行分组、对照方法将患者分为三组，甲组40例，单用非洛地平缓释片（钙拮抗剂）10 mg/d；乙组44例，非洛地平缓释片5 mg/d+缬沙坦（血管紧张素Ⅱ受体阻滞剂ARB）80 mg/d；丙组46例，非洛地平缓释片5 mg/d +厄贝沙坦氢氯噻嗪150 mg/d。结果：治疗8周后，丙组收缩压（SBP）和舒张压（DBP）达标率分别为60.9%和95.6%，较甲组SBP达标率（15.0%、80.0%）和乙组（9.1%、68.2%）高，差异有统计学意义（P＜0.05或0.01）。甲组总不良反应发生率（27.5%，11/40）与乙组（4.5%，2/44）、丙组（8.7%，4/46）比较，P均＜0.05。结论：钙拮抗剂联合ARB复合剂（ARB+小剂量利尿剂）治疗老年高血压疗效理想，且不良反应低。 　　[关键词] 高血压抗高血压药物；厄贝沙坦；利尿药 　　[中图分类号] R544.1[文献标识码]B [文章编号]1673-7210（2011）02（c）-061－０2 　　Effect observation of treating age patients with hypertension by multi-antihypertensive drugs 　　HAO Dejing1, LUO Li2, TANG Chunyan1, QU Jianhua3 　　[1.Emergency Center, No. 4 Clinical Hospital Attached to Jilin University (FAW Hospital),Changchun 130011,China;2.ICU, No. 4 Clinical Hospital Attached to Jilin University (FAW Hospital),Changchun 130011,China; 3.Pharmacy Department, No. 4 Clinical Hospital Attached to Jilin University (FAW Hospital),Changchun 130011,China] 　　[Abstract] Objective: To discuss the effect of treating age patients with hypertension by using multi-antihypertensive drugs. Methods: The patients were divided into three groups randomly. There were 40 patients in group A;each one in this group took the single drug felodipine（calcium antagonist）10 mg/d. There were 44 patients in group B;each one in this group took the drug felodipine（calcium antagonist）5 mg/d and valsartan（angiotensinⅡreceptor blocker,ARB）80 mg/d. There were 46 patients in group C;each one in this group took the drug felodipine（calcium antagonist）5 mg/d, Irbesartan and hydrochlorothiazide 150 mg/d. Results: After the treatment of 8 weeks, the patients′ SBP in group C was lower than 140 mm Hg and DBP was lower than 90 mm Hg. The ideal rate was 60.9% and 95.6% respectively. They were higher than the rates of SBP and DBP in group A (15.0%, 80.0%)and that in Group B(9.1%, 68.2%), all P＜0.05. Adverse reaction rates in group B(4.5%, 2/44) and in group C(8.7%, 4/46) were lower than that in group A(27