低血钾型周期性麻痹41例临床剖析c.docVIP

低血钾型周期性麻痹41例临床剖析c 　　[摘要]目的 分析低血钾型周期性麻痹（HypoPP）的临床特点。 方法 回顾性分析41例低血钾型周期性麻痹患者的临床资料。 结果 在41例患者中，原发性28例，继发性13 例，其中继发于甲亢 11例，原发性醛固酮增多症2例；HypoPP主要表现为四肢弛缓性肌无力，大多有诱发因素，男性多发；发作时血钾低于正常，部分患者可出现肌酸激酶升高，未见发生恶性心律失常及呼吸肌麻痹。 结论 HypoPP 以肌无力伴低钾血症为其临床特点，早期诊断及时补钾治疗预后较好，对继发性 HypoPP 患者应强调病因治疗。 　　[关键词]低钾血症；周期性麻痹；原发性；临床分析 　　[中图分类号] R591.1 [文献标识码] B [文章编号] 2095-0616（2014）16-185-03 　　Clinical analysis of 41 patients with hypokalemic periodic paralysis 　　WANG Yong YANG Jing 　　Department of Emergency， the First Peoples Hospital of Hefei， Hefei 230061， China 　　[Abstract] Objective To investigate the clinical features of hypokalemic periodic paralysis （HypoPP） . Methods The clinical data of 41 patients with HypoPP were retrospectively studied and summarized. Results In 41 cases， idiopathic 28 cases， secondary13 cases. 11 were secondary from hyperthyroidism， 2 were primary aldosteronism. The main clinical features of HypoPP were sluggish myoasthenia of four limbs， Most patients had obvious incentives， It had a predilection in young men. Serum potassium levels of all patients were lower than the normal range and creatine kinase levers of some patients were higher than the normal， No patients experienced respiratoryparalysis and malignant arrhythmia when disease onset. Conclusion HypoPP is a disorder characterized by myoasthenia accompanied by lowered serum potassium levels， patients with early diagnosis and replenishment of potassium in time had good prognosis. Etilogical treatment should be underlined for secondary cases. 　　[Key words] Hypokalemia； Periodic paralysis； Primary； Clinical analysis 　　低血钾型周期性麻痹（hypokalemic periodic paralysis，HypoPP）是一组以周期性发作的弛缓性骨骼肌无力为特点的离子通道疾病， 常伴有低钾血症， 严重者可致恶性心律失常、呼吸肌麻痹而危及生命。现将2008 年7月～2013年9月本科接诊的41例 HypoPP 患者的临床资料进行回顾分析报道如下。 　　1 对象与方法 　　1.1 研究对象 　　收集合肥市第一人民医院急诊住院部2008 年7月～2013年9月低血钾型周期性麻痹住院患者41例。HypoPP患者男40例，女1例；年龄 16～67岁，平均（35.0±11.5）岁。 　　1.2 研究方法 　　查阅所有入选患者住院病例，回顾性分析所有患者临床资料，包括患者性别、年龄、发病诱因、既往发病史、周期性麻痹家族史、临床表现、发作时血钾及肌酸激酶水平、甲状腺功能、心电图以及治疗情况，分析其临床特点。