噻托溴铵治疗中重度稳定期慢性阻塞性肺疾病疗效剖析.docVIP

噻托溴铵治疗中重度稳定期慢性阻塞性肺疾病疗效剖析 　　doi：10.3969/j.issn.1007-614x.2014.1.11 　　摘 要 目的：探讨分析噻托溴铵治疗中重度稳定期慢性阻塞性肺疾病（COPD）的临床疗效。方法：收治稳定期中重度COPD患者56例，随机将其分为观察组28例和对照组28例。对照组仅采用常规治疗，观察组在此基础上加用噻托溴铵，比较两组临床疗效、肺功能及血气分析指标。结果：观察组总有效率96.4%显著高于对照组总有效率82.1%，差异有统计学意义（P0.05）；两组肺功能及血气指标较治疗前均明显改善，且观察组肺功能及血气各项指标显著优于对照组，差异有统计学意义（P0.05）。结论：噻托溴铵治疗中重度稳定期慢性阻塞性肺疾病效果显著，能持续改善患者肺功能及血气各项指标，发生不良反应较少，患者耐受性情况较好。 　　关键词 噻托溴铵 中重度 稳定期 COPD 　　Abstract Objective：To investigate the curative effect of tiotropium bromide in the treatment of moderate and severe stable chronic obstructive pulmonary disease.Methods：To receive and cure 58 cases of moderately severe stable COPD patients were randomly divided into the observation group 28 cases and the control group 28 cases.The control group patients only received routine treatment，on this basis，the observation group combined with tiotropium bromide，compare two groups of clinical curative effect，pulmonary function and blood gas analysis index.Results：The total effective rate of the observation group was 96.4%，the control group was 82.1%，the observation group was significantly higher than the control group，the difference was statistically significant（P0.05）.The pulmonary function and blood gas indes of the two groups patients compared with those before treatment were significantly improved，and the pulmonary function and blood gas indes of the observation group were significantly better than the control group，the difference was statistically significant（P0.05）.Conclusion：The effect of tiotropium bromide in the treatment of moderate and severe stable chronic obstructive pulmonary disease is remarkable，tiotropium bromide can continue to improve lung function and blood gas indexes in patients，less adverse reactions，patients tolerance is better，is worth application and promotion in the clinical. 　　Key words Tiotropium bromide；Moderate and severe；Stable；COPD 　　慢性阻塞性肺疾病（COPD）是临床上常见且严重的慢性呼吸系统疾病，治疗周期长，且病情易反复发作，严重影响患者的劳动能力和生活质量[1]。COPD的主要特征是进行性气流阻塞，可伴有气道的高反应状态，气流阻塞可能部分逆转。研究发现，乙酰