P急性加重期脂联素和炎症因子检测及其临床意义.docVIP

COPD急性加重期脂联素和炎症因子检测及其临床意义 罗敏 (湖北省大冶有色金属集团公司总医院呼吸内科湖北黄石445005) 】目的：检测慢性阻塞性肺疾病(COPD)急性加重期患者脂联素和 炎症因子，并研究其临床意义。方法：检测COPD急性加重期患者(AECOPD组) 和正常人(CON组)脂联素、hs-CRP、TNF-alpha;、IL-6和IL-8并比较其差异, 分析 AECOPD 组患者脂联素、hs-CRP、TNF-alpha;、IL-6 和 IL-8 与 APACHE II 评分 的相关性。结果：AECOPD患者脂联素显著低于CON组，hs-CRP、TNF-alpha;、 IL-6和IL-8均显著高于CON组,差异均具有统计学意义(均Plt;0.001)o AECOPD 组患者脂联素与 APACHE II评分呈负相关(rslt;O, Plt;0.05), hs-CRP、TNF-alpha;、 IL-6 和 IL-8 与 APACHE II 评分均呈正相关(均 rsgt;O, Plt;0.05)。结论:COPD 急性加重期患者脂联素显著降低，hs-CRP、TNF-alpha;、IL-6和IL-8显著升高, 可作为COPD急性加重期病情评估的标志物。 关键词】COPD；急性加重期；脂联素；炎症因子；临床意义 】R446 】A 】2095-1752 (2015) 13-0034-02 The clinical significance of the detection for adiponectin and inflammatory factor in the acute aggravating period of COPD Luo Min. General Hospital of Daye Nonferrous Metals Group Company, Hubei Province, Huang shi 445005, China Abstract】 Objective Detection chronic obstructive pulmonary disease (COPD) patients with acute aggravating period of adiponectin and inflammatory factor, and study its clinical significance. Methods Detection COPD patients with acute exacerbation period (AECOPD) and normal group (CON) adiponectin, hs CRP, TNF alpha, IL - 6 and IL - 8, and compares their differences, Analysis of the correlation. Results Adiponectin AECOPD patients was significantly lower than CON group. The hs CRP, TNF alpha, IL - 6 and IL ? 8, significantly higher than that of CON group, difference has statistical significance （P lt; 0.001）. Conclusions COPD patients with acute aggravating period of adiponectin decreased significantly, the hs CRP, TNF alpha, IL - 6 and IL - 8, a significant rise, can be used as COPD acute aggravating period of condition evaluation markers. ［Key words］ COPD; Acute exacerbation period; Adiponectin; Inflammation factors; Clinical significance 慢性阻塞性肺疾病（Chronic obstructive pulmonary disease，COPD）的发病机 制与呼吸道炎症细胞激活及释放多种炎症因子损伤气道密切相关，包括高敏C 反应蛋白（hs-CRP）、TNF-alpha;和白介素等在内的炎症因子均参与COPD发生、 进展及转归［1,2］。脂联素对COPD气道炎症反应具有双向调控作用，既有促进炎 症反应作用，又冇抑制炎症反应作用［3】。本研究检测CO