早期非小细胞肺癌立体定向放射治疗疗效及生存质量剖析.docVIP

早期非小细胞肺癌立体定向放射治疗疗效及生存质量剖析 　　【摘要】 目的：分析体部伽玛刀立体定向放射治疗早期非小细胞肺癌的疗效、生存质量及毒副作用。方法：回顾性分析2004年10月-2011年3月于本院接受体部伽玛刀立体定向放射治疗的58例早期非小细胞肺癌患者的临床资料。结果：58例全部按计划完成治疗，原发灶近期完全缓解率56.9%，部分缓解率20.7%，稳定率1.7%，总有效率79.3%；1、2、3年总生存率分别为86.2%、75.9%、67.2%，治疗后3年内肿瘤局部复发、转移共23例，死亡19例。因复发、转移而死亡12例，非肿瘤死亡者7例；放疗后焦虑、呼吸困难、咳嗽患者少于治疗前，比较差异均有统计学意义（P0.05）；副反应较少，放射性肺炎占24.1%（14/58）；放射性食管炎：中央型肺癌8例占13.7%（8/58）。白细胞下降Ⅰ级占15.5%（9/58），结论：体部伽玛刀治疗早期非小细胞肺癌近期疗效及生存率好，能明显改善患者情绪功能及生活质量，副作用小，是非手术治疗早期非小细胞肺癌的一种疗效好的局部治疗手段。 　　【关键词】 早期非小细胞肺癌； 立体定向放射治疗； 疗效分析； 生存质量分析 　　Analysis of Curative Effect and Living Quality of Stereotactic Radiotherapy in Treating Early-Stage Non-Small Cell Lung Cancer/WU Tie-ying，LI Gai-lan，HUANG Yu-sheng，et al.//Medical Innovation of China，2015，12（26）：029-032 　　【Abstract】 Objective：To study the curative effect，living quality and side effect of body-gamma knife radiotherapy in treating with early-stage non-small cell lung cancer.Method：The clinical data of 58 non-small lung cancer patients who were treated with rotary body gamma knife in our hospital from October 2004 to March 2011 were retrospectively analyzed.Result：All the 58 cases completed the treatment on schedule.The recent complete remission rate of the primary lesion was 56.8%，partial remission rate was 20.7% and the stability rate was 1.7%.The overall response rate was 79.3%.The survival rates of 1，2 and 3-year after the treatment were 86.2%，75.9% and 67.2%.3 years after the treatment，there were 23 cases with neoplasm local recurrence and metastasis.19 cases died，among them，12 cases died of recurrence and metastasis and 7 cases didn’t die of neoplasm.The amount of patients with anxiety，expiratory dyspnea and cough after the treatment were less than before treatment，the differences were statistically significant（P0.05）.The complications of radiotherapy were less，24.1%（14/58） of the patients were with radiation pneumonitis，13.7% （8/58）of the patients were with radiation esophagitis and 15.5%（9/58） of the patients were with stage Ⅰ leucopenia.C