SOX102cEDNRB在人胚胎肠神经系统发育中的表达.pdfVIP

关键词 肠神经系统先天性巨结肠 SoxlOEDNRB 人胚胎 3 ·英文论著摘要· SOXIO，EDNRB enteric expressionduring inhuman systemdevelopmentembryos ective Obj themaincauseof intestinm Hirschsprung’Sdisease饵SCR)is congenital withall of1／5000livebirthsandiScharaeterisedthe obstructionincidence by absenceorreductionofenteric avariableofthe gangliaalong length isahallmarkof whenneuralcrest congenitalaganglionosis，whichHSCR,arises failto colonizethe tract．Theenteric ceils completely developinggastrointestinal nervous formation theCO-ordinated system requires differentiationandsurvivalofneuralcrest the gut． cells(NCC)withindeveloping 11leentericnervous intrinsicinnervationofthe system(ENS)，the neuronsand cellsthat tract,is ofa numberof gastrointestinalcomposedlarge glia ofentericneuronsisthe arederivedfromNCC．Themost source important vagal neural studieshave reachthestomachin crest．Embryologicalconfirmed，NCCs week reachthe inweek7thinhuman whole 5th,and hindgut embryos,theprocess endinthe1