功能性胃肠疾病诊治新专业技术标准.pptVIP

PPI与SIBO和IBS PPI可致胃、十二指肠及小肠细菌生态改变。有研究显示，PPI治疗相关的SIBO可引起患者非结合型胆汁酸浓度增加，小肠运动加快。而PPI引起的最常见不良反应是腹痛、腹胀、便秘和腹泻，这些与IBS的症状一致。　 意大利学者的研究显示，PPI治疗组患者SIBO发生率显著高于IBS组和对照组，PPI应用时间是发生SIBO的预测因素。这似乎提示PPI治疗是SIBO的潜在原因。　 GERD-PPI-SIBO-IBS Brennan M.R. et al. Bacterial Overgrowth and Irritable Bowel Syndrome: Unifying Hypothesis or a Spurious Consequence of Proton Pump Inhibitors? American Journal of Gastroenterology SIBO might be a byproduct of the disproportionate use of proton pump inhibitors (PPIs) in IBS, as follows: (1) IBS patients are more likely than controls to receive PPI therapy; (2) PPI therapy may prom