18FFDG PETCT显像在早期诊断鼻咽癌放疗后复发中的应用价值.docx

优秀毕业论文 精品参考文献资料 18F-FDG PET/CT 显像在早期诊断鼻咽癌放疗后复发中的应用价值 中文摘要 中文摘要 目的 探讨 18F-FDG PET/CT 显像在早期诊断鼻咽癌放疗后复发中的临床应 用价值。 方法 回顾性分析 57 例鼻咽癌(nasopharyngeal carcinoma,NPC)放疗后患者 18F-FDG PET/CT 和 MRI 影像学资料，以组织病理学诊断和（或）长期临床随访资 料为标准，其中复发组 43 例，未复发组 14 例。 结果 18F-FDG PET/CT 和 MRI 诊断原发性鼻咽癌放疗后复发的灵敏度、特 异度、准确率、阳性预测值和阴性预测值分别为 97.6%和 81.4%、71.4%和 57.1%、 91.2%和 75.4%、91.3%和 85.4%、90.9%和 50.0%；PET/CT 灵敏度、准确率及阴性 预测值均高于 MRI，差异有统计学意义（P0.05）；两者间特异度和阳性预测值 差异无统计学意义（P0.05）。复发组 SUV 均值为 7.98±3.29 ,未复发组 SUV 均 值 3.31±2.09，差异有显著统计学意义(P0.05)。 结论 18F-FDG PET/CT 在早期诊断鼻咽癌放疗后复发上具有高灵敏度和准 确率，是一种可靠的临床诊断工具。 关键词：鼻咽癌；复发；正电子发射断层显像技术；磁共振成像；标准摄取值 作 者： 指导老师： II II 英文摘要 18F-FDG PET/CT 显像在早期诊断鼻咽癌放疗后复发中的应用价值 The application value of 18F-FDG PET/CT in early detecting the recurrence of nasopharyngeal carcinoma after radiotherapy Abstract Objective To investigate the clinical value of 18F-FDG PET/CT in early detecting the recurrence of nasopharyngeal carcinoma after radiotherapy. Methods A retrospective analysis of 57 patients with NPC after radiotherapy with 18F-FDG PET/CT and MRI image data，in order to histopathological or clinical follow-up data for the standard. Recurrent group has 43 cases, while non-recurrent group with 14 cases. Results For detecting the recurrence of post-radiation NPC, the sensitivity of PET/CT and MRI were 97.6% and 81.4%, respectively; specificity, 71.4% and 57.1%; accuracy, 91.2% and 75.4% ; positive predictive value (PPV), 91.3% and 85.4% ; negative predictive value （NPV）, 90.9% and 50% , respectively. The sensitivity , accuracy and NPV of PET/CT are higher than MRI, with significant difference （P0.05）, while specificity and PPV without significant difference （P0.05）. The average standard uptaken value (SUV) was 7.98±3.29 in the recurrent group, while 3.31±2.09 in the non-recurrent group, with significant difference (P0.05). Conclusion 18F-FDG PET/CT have high accuracy rate and sensitivity in early detecting to the recurrence of nasopharyngeal carcinoma after radiotherapy, wh