2型糖尿病肥胖与胰岛功能 GLP1及GC水平的相关性研究.docx

优秀毕业论文 精品参考文献资料 目 录 中文摘要············································································································1 英文摘要············································································································3 英文缩写············································································································5 研究论文 2 型糖尿病肥胖与胰岛功能、GLP-1 及 GC 水平的相关性研究 前言············································································································6 材料与方法································································································7 结果··········································································································10 附图··········································································································12 附表··········································································································16 讨论··········································································································25 结论··········································································································29 参考文献··································································································30 综述 肥胖相关慢性炎症与2型糖尿病························································33 中 中 文 摘 要 PAGE 1万方数据 PAGE 1 万方数据 2 型糖尿病肥胖与胰岛功能、GLP-1 及 GC 水平的相关性研究 摘 要 目的：观察不同 BMI 及不同腰围(WC)的 2 型糖尿病患者胰岛功能及 血清 GLP-1 和 GC 水平，探讨肥胖与 2 型糖尿病患者的胰岛功能、GLP-1 和 GC 水平的相关性。 方法：选取 2015 年 3 月~2015 年 11 月，于河北医科大学第三医院就 诊的 2 型糖尿病患者 85 例，依据 BMI 将研究对象分为正常 BMI 组、超重 组和肥胖组；依据 WC 分为腹型肥胖(Abdominal obesity, AO)组和非腹型 肥胖（Non-abdominal obesity, NAO）组。所有受试者均于禁食 8~12 小时 后行口服 75g 葡萄糖耐量试验（oral glucose tolerance test, OGTT），分别 采集 0、30min、120min 时的肘静脉血，检测各时间点血样的血糖（BG）、 胰岛素（INS）、C 肽（CP）、胰高血糖素样肽-1（GLP-1）和胰高血糖 素（GC）水平，并计算胰岛素敏感指数（ISI）、稳态模型胰岛素抵抗指 数（HOMA-IR）、稳态模型胰岛 β 细胞功能指数（HOMA-β）、早相胰 岛素分泌指数（△ I30/△ G30）和晚相胰岛素分泌指数（AUCins/AUCg）。 结果： 不同 BMI 组比较：超重组和肥胖组的 AUCi