聪耳2号方治疗肾虚血瘀型突发性耳聋的临床研究-中西医结合临床专业论文.docxVIP

— — PAGE 1— 摘 要 聪耳 2 号方治疗肾虚血瘀型突发性耳聋的临床研究 摘 要 目的：观察聪耳2号方治疗肾虚血瘀型突发性耳聋的临床疗效，客观评价其治疗 肾虚血瘀型突发性耳聋的有效性；评价其对纯音听阈测定、耳鸣残疾评估评分、血 浆降钙素基因相关肽的影响；探索一种疗效可靠的治疗肾虚血瘀型突发性耳聋的中 药制剂。方法：根据随机、对照的原则，将符合肾虚血瘀型突发性耳聋标准的95例 患者随机分为两组，治疗组49例，对照组46例。治疗组患者给予聪耳2号方口服加中 西医综合常规疗法，对照组给予中西医综合常规疗法，两周为一疗程，观察两组患 者治疗前及治疗两周后纯音听阈测定值、耳鸣残疾评估评分、血浆降钙素基因相关 肽水平的变化。结果：两组患者治疗后听力均有改善，治疗组有效率89.80%，对照 组有效率76.09%，两组差异有统计学意义（P＜0.05）。聪耳2号方在改善耳鸣残疾评 估评分、血浆降钙素基因相关肽水平与对照组比较有统计学意义（P＜0.05）。结论： 聪耳2号方能提高肾虚血瘀型突发性耳聋患者的听力，改善耳鸣症状，并能升高患者 血浆降钙素基因相关肽水平。聪耳2号方对肾虚血瘀型突发性耳聋有较好的临床疗 效，值得临床推广。 关键词：肾虚血瘀型突发性耳聋；临床研究；中医药疗法；聪耳2号方 新疆医科大学医学硕士学位论文 Clinical study of Congererhaofang on sudden sensorineural hearing loss（kidneydeficiency of blood stasis） Abstract Objective: To study the effect of Congererhaofang in the treatment of sudden sensorineural hearing loss （kidney deficiency and blood stasis） of the clinical efficacy and adverse reactions；to objective evaluation of its treatment of sudden sensorineural hearing loss（kidney deficiency and blood stasis） effectiveness and safety; to explore a reliable, safe, highly treatment using Traditional Chinese Medicine on sudden sensorineural hearing loss（kidney deficiency and blood stasis）. Methods: 95 sudden sensorineural hearing loss （kidney deficiency and blood stasis） patients were randomly divided into two groups, 49 cases as treatment group, in which a basic treatment combined with Congererhaofang, 46 cases as control group, with a basic treatment. Two weeks for one course of treatment. Observed the change of pure-tone hearing threshold measured, tinnitus handicap inventory, plasma calcitonin gene-related peptide before and two weeks after the treatment. Results: After two weeks treatment，the two groups improve the level of hearing（89.80% in the treatment group and 76.09% in the control group）, the two groups have significant differences (P0.05). There are significant differences in Congererhaofang improving the tinnitus handicap inventory and the level of plasma calcitonin gene related peptide compared wi