2型糖尿病脂联素水平与心脑血管病变关系的分析.docx

优秀毕业论文 精品参考文献资料 THE RELATIONSHIP OF ADIPONECTIN AND CARDIAC AND CEREBRAL ANGIOPATHY IN THE PATIENTS WITH TYPE 2 DIABETES ABSTRACT Objective To analyze the relationship of Adiponectin and the insulin resistance and cardiac and cerebral angiopathy of Type 2 diabetes. Methods Divided the diabetes patients into two groups: group B and group C. The group B was composed with the diabetic patients without macroangiopathy (n: 42) ; The group C was composed of the diabetic patients with the cardiac and cerebral vascular complication (n: 38). The patients of group C had identity cerebral infarction (according to their past history of illness, examination results from computed tomography and magnetic resonance imaging), coronary heart disease [according to their history of angina cordis, ocardial infarction, ectrocardiogram and (or) coronary arteriongraphy confirm that at least one vascular had narrow degree more than fifty percent]. At the same time, 35 examined healthy persons were enrolled in this study as control group (group A) . Their serum adiponectin (ADP) , blood glucose, blood lipid, fasting inlusin were measured. The insulin resistance index (IRI) was calculated. The carotid intima-media thickness (CIMT) was measured. The results were analyzed. Result (1) The lever of serum adiponectin of group B was lower than that of group A (P＜0.01), Group C had the lowest lever of adiponectin among 3 groups (P＜0.01). The patients in groupB and C had more evident metabolic disturbance and insulin resistance than group A. (2) Divide the Type 2 Diabetic to four groups by adiponectin having 25 percent, 50 percent, 75 percent percentile as the boundary.We found that carotid intima-media thickness of the four groups have significant difference with each other. (3) ADP was negatively correlated with CIMT (P＜0.01). (4) Multiple linear stepwise regression analysis suggested that decrease of adiponectin and high-density lipoprotein cholesterol and the increase of triglycerides were the da