丹参温中饮加减治疗功能性消化不良上腹痛综合征（寒凝气滞血瘀证）的临床观察-中医内科学(脾胃)专业论文.docx

成都中医药大学 成都中医药大学 2015 届硕士毕业论文 万方数据 万方数据 中文摘要 目的：本研究以寒凝气滞血瘀型功能性消化不良上腹痛综合征（EPS）作为临床 疗效的观察切入点，从理论和临床上探讨丹参温中饮加减对此病证的临床疗效。 方法：以绵阳市中医医院门诊患者为研究对象，将 64 例符合纳入标准的 EPS 患 者随机分为 2 组，治疗组 31 例予丹参温中饮加减治疗，对照组 33 例予奥美拉唑、 多潘立酮治疗，4 周为 1 疗程，均治疗 1 疗程。治疗结束后，观察治疗前后症状 变化及停药一月内复发情况，经统计学处理，从治疗前后症状积分、综合疗效及 抗复发效果等方面进行对比。 结果： ⑴治疗组的总有效率为 93.4%，对照组的总有效率为 67.7%，两组的总有效 率比较差异有统计学意义（P＜0.05），说明治疗组疗效优于对照组。 ⑵治疗后，两组药物对 EPS（寒凝气滞血瘀型）患者的临床症状的缓解均具 有一定作用，但治疗组的疗效明显强于对照组，表现在治疗组所有症状均有缓解， 但对照组对胸胁胀痛、形寒肢冷、泛吐清水无改善，同时对于胃脘疼痛、胃脘胀 满、反酸、纳呆、嗳气等症状的改善，治疗组明显优于对照组。 ⑶治疗组与对照组均未出现不良反应（或不良事件）。 ⑷停药 1 月后，治疗组复发率为 20.0%,对照组为 46.7%，差异具有统计学意 义，说明治疗组抗复发效果明显高于对照组。 结论：本临床研究表明，治疗组以丹参温中饮加减治疗寒凝气滞血瘀型上腹痛综 合征在改善患者临床症状、降低复发率等综合疗效方面有明显优势，具有较好的 临床应用前景。 关键词：功能性消化不良；上腹痛综合征；寒凝气滞血瘀；临床研究 1 成都中医药大学 成都中医药大学 2015 届硕士毕业论文 万方数据 万方数据 ABSTRACT Objective:This study makes observation of the clinical efficacy of the EPS(Epigastric Pain Syndrome) that is a subtype of FD as the starting point. Clinical efficacy of Danshen Wenzhong Decoction were evaluated through both the theoretical and clinical aspects. Method:Take the outpatients of Mianyang city hospital as the research object,64patients that conformed to the diagnostic criteria of EPS were randomly divided into two groups.31 cases of the treatment group took Danshen Wenzhong Decoction,33cases of the control group took western medicine that contained Domperidone and Omeprazol capsules,four weeks for a course,both are treated as acourse.After the end of treatment,observed the symptoms before and after treatment and relapse within one month after stopping drug,by statistical analysis,compared the score of the symptoms before and after treatment、comprehensive alleviation effect before and after treatment and anti-relapse effect. Results: ⑴ The total effective rate of the treatment group is 93.4%.The total effective rate of the control group is67.7% .The total curative effect between the two groups has significant difference (P＜0.05),and the treatment group is superior to the control group. ⑵ After treatment, two