大半夏汤治疗化疗所致呕吐的胃肌电生理实验研究及临床疗效观察-中医内科学(消化方向)专业论文.docx

中文摘要 目的 通过对胃起搏区的电生理活动的观察来探讨大半夏汤对抗化 疗药所致恶心呕吐的作用机理，从而寻求中药止呕和化疗药致呕之间是否可 以通过中药对 Cajal 间质细胞（ICC）的调控来解释；临床观察大半夏汤用于 治疗化疗所致呕吐的疗效，为中医药治疗化疗后呕吐提供一定的临床依据。 方法 1.采用家鸽腹腔注射顺铂造模，将受试家鸽随机分为空白对照 组、DDP 组、阳性胃复安对照组、高剂量组、中剂量组、低剂量组，造模成 功后连续给药 7 天，给药期间详细观察记录每只家鸽的一般情况，给药第 7 天后禁饮禁食 24h，用 BL-410 生物机能实验系统记录胃起搏区的慢波频率。 2. 临床观察 30 例化疗致呕患者，化疗后第二天开始用大半夏汤汤剂治疗， 连续用药 14 天后，通过对治疗前后患者的恶心、呕吐分级及身体一般状况 Karuafsky 积分统计分析，总结评定疗效。 结果 1.高、中、低剂量组与 DDP 组相比，平均慢波频率及慢波异 常节律指数均有统计学意义（P＜0.05）。2.。治疗前后患者恶心、呕吐症状 比较均有统计学意义；大半夏汤改善患者身体一般状况有效率为 83.3%；恶 心呕吐症状完全缓解 3 例，部分缓解 20 例，总有效率为 76.67%。 结论 1.大半夏汤止呕的机制与其纠正胃起搏区的胃肌电慢波频率 及节律有关，从而推测其与大半夏汤对 ICC 的调控作用有关。2.大半夏汤治 疗化疗所致呕吐疗效较好，特别是对患者一般身体状况改善效果佳。 关键词 化疗呕吐 ICC 大半夏汤 胃肌电 临床观察 ABSTRACT Objective：To research the mechanism of the Chinese Compound Prescription—DaBanXiaTang(DBXT) treating the vomiting on Pigeon by using cisplatin(DDP). In order to seek traditional Chinese medicine and chemotherapy antiemetic drug to vomit through the medicine between the Cajal interstitial cells of the (ICC) to explain the regulation and control. To observe the effect of DBXT treating the vomiting in Clinical, so as to Providing the Clinical evidence of Traditional Chin Medicine treatment ese the CINV in the future. Methods：1.Used the pigeon model of the intraperitoneal injection of cisplatin. Packet Subjects pigeon by random：Blank control group、DDP group、Positive control group、 high-dose of DBXT group、Middle -dose of DBXT group、Low-dose of DBXT group；After modeling success，Taking the DBXT fourteen days. In the period, Observe the general situation of each pigeon Carefully. 14th days after taking the DBXT, prohibited food and drink, then recording the frequency of Slow-wave on the Gastric pacing District by using BL-410 Biological function of experimental system.2. To observe 30 patients in clinical,using DBXT to treatment the vomiting on the second day after the chemotherapy. After giving the DBXT 14 days， Do the Statistics and analyse the vomiting grade and the general state of physical before and after tre