医学免疫学教学课件汇编-细胞应答.pptVIP

细胞免疫应答的效应 *黏附分子使效应细胞与靶细胞接触 *识别MHC/Peptide *释放细胞因子或杀伤靶细胞 辅助性Ｔ细胞 (Helper T cells) 激活Ｂ细胞产生抗体 激活Mf，增强其杀伤和抗原递呈能力 辅助Ｔ杀伤细胞的活化 杀伤性Ｔ细胞（Cytotoxic T cells, Tc) (Cytotoxic T lymphocytes, CTL) 杀伤机制 穿孔素(perforin)穿孔, 丝氨酸蛋白酶，酶解蛋白，细胞死亡 CTL释放TNF-a和IFN-g, 与靶细胞表面受体结合，细胞死亡 CTL表面的FasL表达水平增高，与靶细胞表面的Fas交联，凋亡 免 疫 后 天 数 外周血中抗原特异性T细胞的比率 感应阶段 初次免疫 再次免疫 1/10000 1/1000 1/100 0 7 14 21 28 35 42 T 细 胞 免 疫 应 答 的 一 般 规 律 Immunological memory Memory T Cells: Resting state Long lived (continuously renewal) Easily triggered (do not need co-stimulatory molecules) Responsible for maintaining immunological memory 薛殷彤 副教授 北京大学医学部 免疫系 Tel/Fax: 010-8280 1747 Email: maybegood@ 1991, Dept. Basic Medicine, BMU, BM 1999, MTC, Karolinska Institute, Ph.D 2000, HSC, BU, Associate Prof. PUBLICATIONS 1. Xue Y. Castanos-Velez E. Biberfeld P. Jondal M. Anti-CD3 induced thymocyte apoptosis in vivo require the antibody Fc domain. Scandinavian Journal of Immunology. 51(5):441-6, 2000 May. Abstract | Complete Reference 2. Pazirandeh A. Xue Y. Rafter I. Sjovall J. Jondal M. Okret S. Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB Journal. 13(8):893-901, 1999 May. Abstract | Complete Reference 3. Xue Y. Chomez P. Castanos-Velez E. Biberfeld P. Perlmann T. Jondal M. Positive and negative thymic selection in T cell receptor-transgenic mice correlate with Nur77 mRNA expression [published erratum appears in Eur J Immunol 1997 Oct;27(10):2748]. European Journal of Immunology. 27(8):2048-56, 1997 Aug. Abstract | Complete Reference 4．A.Pazirandeh, Y.Xue, T.Prestegaard, M.Jondal and S.Okret. Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis. FASEB Journal. In press (10.1096 FJE 01-0891 COM) 5. Zhang J. Xue Y. Jondal M. Sjovall J. 7alpha-Hydroxylation and 3-dehydrogenation abolish the a