生化--郑利民课件 号转导2－生化课08.pptVIP

Signal-Transduction Pathways信号转导通路 (2)郑利民 2008 珠海zhenglm@mail.sysu.edu.cn Biosignaling: How are they regulated? PARTⅠ 1 Basic characteristics of signal transduction 2 Four general types of signal transducers PARTⅡ 1 Regulatory mechanisms 2 Some diseases caused by defects in the biosignaling pathways Regulatory mechanisms of Bio-signals 3.1 Phosphorylation as a regulatory mechanism 3.2 Regulation of transcription by steroid hormones 3.3 Regulation of the cell cycle by protein kinases Protein Kinases 1: GPCRs (5%), 2: Kinases (2.8% genome) Protein kinases (534 human kinases) Mechanisms