内源性调性T细胞在SAH后脑血管痉挛及脑损伤中的作用.ppt

汇报人：张金卉 导师：孙保亮 研究的目的及意义 国内外相关文献 A serial response of immunoreactive cells, which resembles that of the chronic allergic reaction observed in autoimmune diseases or delayed-type hypersensitivity, exists in the subarachnoid space after subarachnoid hemorrhage. The present results suggest that the initial response in cellular immunity, which is followed by humoral immunity and eicosanoid reactions, plays a role in eliciting the development of cerebral vasospasm. 蛛网膜下腔出血后脑血管痉挛分子机制的研究进展 与NO代谢无关的CVS Statin-Induced T-Lymphocyte Modulation and Neuroprotection Following Experimental Subarachnoid Hemorrhage Statins in fl uence immune system activities through echanisms independent of their lipidlowering properties. T cells can be subdivided based on cytokine secretion patterns into two subsets: T-helper cells type 1 (Th1) and type 2 (Th2). Independent laboratory studies have shown statins to be potent inducers of a Th2 switch in immune cell response and be neuroprotective in severalmodels of central nervous system (CNS) disease. This study was the fi rst to evaluate the immune modulating effects of statins in subarachnoid hemorrhage (SAH). The present study elucidated the potential role of a Th2 immune switch in statin provided neuroprotection following SAH. Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage Elevated cerebral interstitial pro-MMP-9 relates to early brain injury in aSAH patients. A larger prospective study should be performed to confirm whether patients with prolonged elevation or a second peak of cerebral pro-MMP-9 would be more likely to develop DCI and to confirm whether MMP-9, a mediator of neurovascular injury, would be worth to consider as a predictor of vasospasm. Trehalose treatment suppresses inflammation,oxidative stress, and vasospasm induced by experimental subarac