蛋白药物内耳缓释给药系统的构建与评价-药剂学专业论文.docxVIP

广东药学院学位论文原创性声明 本人郑重声明: 本人所呈交的学位论文，系我个人在导师的指导下 进行研究工作所取得的成果。除文中己特别加以标注和致谢的地方外，不 包含其它个人或机构己经发表或撰写过的研究成果。对本研究做出贡献的 其它个人和集体，均己在文中明确说明和致谢。本人充分意识到本声明的 法律结果完全由本人承担。 学位论文作者签名:俗吗 7 日期= VOI_?年主月对 日 学位论文使用授权的声明 本人完全了解广东药学院有关保留和使用学位论文的规定，学校有权 保留和向有关部门或机构送交本论文的复印件和电子版，允许论文被查阅 和借阅。学校可以将本学位论文的全部或部分内容编入有关数据库，可以 采用影印、缩印或其它复印手段保存和汇编本学位论文。 保密论文在解密后适用本声明。 论文作者签名. 毛今 论文导师签名九制 日期= 2ρI 年 t月2--/ 日 目 录 HYPERLINK \l _bookmark0 摘要 i HYPERLINK \l _bookmark1 Abstract iii HYPERLINK \l _bookmark2 第一章 前言······································································································································· 1 HYPERLINK \l _bookmark3 1 内耳疾病的治疗现状 ················································································································· 1 HYPERLINK \l _bookmark4 2 耳的结构特点及内耳（局部）给药的可行性分析 ································································· 1 HYPERLINK \l _bookmark5 3 纳米粒及其在内耳给药中的应用 ····························································································· 3 HYPERLINK \l _bookmark6 4 温敏凝胶及其在内耳给药中的应用 ························································································· 4 HYPERLINK \l _bookmark7 5 纳米-凝胶复合系统及其在内耳给药中的应用········································································ 5 HYPERLINK \l _bookmark8 6 本课题的研究内容和意义 ········································································································· 6 HYPERLINK \l _bookmark9 第二章 IFNα-2b PLGA 纳米粒的制备与表征················································································· 7 HYPERLINK \l _bookmark10 1 材料············································································································································· 7 HYPERLINK \l _bookmark11 1.1 仪器 7 HYPERLINK \l _bookmark12 1.2 试剂 7 HYPERLINK \l _bookmark13 2 方法···