Interstroke研究高血压是卒中患者首要危险因素.pdfVIP

Articles Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study Martin J O’Donnell, Denis Xavier, Lisheng Liu, Hongye Zhang, Siu Lim Chin, Purnima Rao-Melacini, Sumathy Rangarajan, Shofi qul Islam, Prem Pais, Matthew J McQueen, Charles Mondo, Albertino Damasceno, Patricio Lopez-Jaramillo, Graeme J Hankey, Antonio L Dans, Khalid Yusoff , Thomas Truelsen, Hans-Christoph Diener, Ralph L Sacco, Danuta Ryglewicz, Anna Czlonkowska, Christian Weimar, Xingyu Wang, Salim Yusuf, on behalf of the INTERSTROKE investigators* Lancet 2010: 376; 112–23 Background The contribution of various risk factors to the burden of stroke worldwide is unknown, particularly in Published Online countries of low and middle income. We aimed to establish the association of known and emerging risk factors with June 18, 2010 stroke and its primary subtypes, assess the contribution of these risk factors to the burden of stroke, and explore the DOI:10.1016/S0140- diff erences between risk factors for stroke and myocardial infarction. 6736(10)60834-3 See Comment page 74 Methods We undertook a standardised case-control study in 22 countries worldwide between March 1, 2007, and April *Members listed at end of paper 23, 2010. Cases were patients with acute fi rst stroke (within 5 days of symptoms onset and 72 h of hospital admission). Population Health Research Controls had no history of stroke, and were matched with cases for age and sex. All participants completed a structured Institute, McMaster University, Hamilton, ON, C