TEPORAL(后外侧聂叶).pptVIP

Neural Basis for Verb Processing in Alzheimer’s Disease:An fMRI Study Murray Grossman, Phyllis Koenig, Chris DeVita, Guila Glosser, Peachie Moore, Jim Gee, John Detre, and David Alsop University of Pennsylvania School of Medicine Neuropsychology 2003, Vol. 17, No. 4, 658–674 PSY9118018 Abstract Patients with probable AD have difficulty understanding verbs. To investigate the neural basis for this deficit, the authors used fMRI to examine patterns of neural activation during verb processing in 11 AD patients compared with 16 healthy seniors. Subjects judged the pleasantness of verbs, including MOTION verbs and COGNITION verbs. Healthy seniors and AD patients both activated posterolateral temporal(後外側聶葉) and inferior frontal regions during judgments of verbs. (同時活化只是活化的程度不同) These activations were relatively reduced and somewhat changed in their anatomic distribution in AD patients compared with healthy seniors, particularly for the subcategory of MOTION verbs, but AD patients showed minimal activation in association with COGNITION verbs. (AD對cognition verbs的活化較差) These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing. Introduction Patients with probable AD are thought to have difficulty understanding single words. Patients with AD appear to have greater difficulty with verbs than with nouns. Although exceptional cases have been described, and a recent study involving many axial verbs failed to confirm earlier observations, the verb impairment in AD has been shown with several different techniques, including confrontation naming, word–picture and word–video matching, and word–definition matching. Method Subjects(受試者) We studied 16 healthy, right-handed seniors and 11 patientswith mild-to-moderate dementia diagnosed as probable AD. Materials(材料) two categories of verbs : MOTION verbs