课件：C 反应蛋白临床应.ppt

文章2. 文章3. 血清Ｃ反应蛋白检测在小儿急性呼吸道感染中的应用价值 文章4.外周血C反应蛋白测定对急性上呼吸道感染患儿的诊断意 急性上呼吸道感染患儿CRP与体温的关系 CRP≤10 mg/L 217例,其中T>39℃137例(63.1% ),T<39℃80例(36. 9% ); CRP>10 mg/L34例,其中T>39℃22例(64. 7% ),T<39℃12例(35.3% )。χ2=0. 0312,P>0. 05。说明CRP的数值变化与体温的变化无明显相关。 在CRP>10mg/L的34例中,以CRP作因变量, WBC作自变量,进行相关分析,相关系数(r) =0.556,呈正相关,P<0.01。 文章5.C 反应蛋白、白细胞计数和分类计数的联合检测在新生儿感染中的临床价值 问题：没有病原学证据。 Biomarkers in community-acquiredpneumonia A state-of-the-art review CRP values＜3 mg/L are normal, and values＞10 mg/L indicate significant inflammation . CRP is a sensitive inflammatory biomarker, but it exhibits low specificity. CRP values between 3 mg/L and 10 mg/L may reflect numerous conditions, such as obesity, smoking, diabetes mellitus, uremia, hypertension, low physical activity, oral hormone replacement therapy, sleep disturbances, chronic fatigue, alcohol consumption, depression, aging and other states that do not necessarily include inflammation . A cut-off point of 11 mg/L serum CPR demonstrated a94% sensitivity and 95% specificity in healthy individualsand CRP patients, respectively. These data suggest that CPR values below this point may exclude a confirmed CAP diagnosis. Chalmers et al. (21) concluded that CRP values ＜100 mg/L in CAP patients on the day of admission and four dayslater were independently associated with a low 30-day mortality rate, low probability for mechanical ventilationand/or inotropic support and low rates of complicated pneumonia. A cohort of 53 subjects demonstrated that daily measurements of serum CRP in the patients with severe CAP are useful for identifying the patients with a poor prognosis, and this biomarker is a better predictor than the commonly used markers of infection, such as body temperature and leukocyte count. This study also demonstrated that shorter antibiotic therapy might exhibit the same efficacy with less toxicity in patients with a rapid drop in CRP levels,.. Recent research has focused on the use of high-sensitivity C-reactiv