嗜肺军团菌主要毒力因子和细胞免疫反应.PDFVIP

·342 · 中华临床医师杂志( 电子版)2014 年1 月第8 卷第2 期 Chin J Clinicians(Electronic Edition),January 15,2014,Vol.8,No.2 ·综述· 嗜肺军团菌主要毒力因子与细胞免疫反应 严慧 朱庆义 【摘要】 嗜肺军团菌是胞内的寄生菌，主要以细胞免疫为主，是引起社区获得性和医院内感染 性肺炎的重要病原体，其致病性与毒力因子密切相关。Dot/IcmⅣ分泌系统是嗜肺军团菌的重要毒力 因子，能诱发大量底物效应蛋白，激活免疫调控因子如NF-κB ，调控嗜肺军团菌细胞内的生长繁殖。 该细菌表面主要毒力因子如Mip 蛋白、鞭毛蛋白和LPS 脂多糖等，与嗜肺军团菌侵染和繁殖能力有 关，在细胞免疫反应中具有重要作用。本文简要概述了嗜肺军团菌几个主要毒力因子、致病性以及 与寄主免疫之间的相互关系。 【关键词】 军团病杆菌，嗜肺； 毒力因子类； 先天免疫； Dot/IcmⅣ分泌系统 Major virulence factors of legionella pneumophila and cell immune response Yan Hui, Zhu Qingyi. Guangzhou Kingmed Center for Clinical Labortory, Guangzhou 510330, China Corresponding author: Zhu Qingyi, Email: zqy@ 【Abstract 】 Legionella pneumophila (L. pneumophila) is an intracellular pathogen, it is a common cause of community-acquired respiratory tract infections and an occasional cause of nosocomial pneumonia. The pathogenicity is closely related to its virulence factors. The main protective role was played by the cellular responses after L. pneumophila infection. The Dot/IcmⅣ type secretion system is the main virulence factor of L. pneumophila , secretes a large number of effector proteins into infected cells. These effectors activate immune regulator factors like NF-κB, and mediated the L. pneumophila intracellular growth and replication. The other main virulence factors, such as Mip, flagellin and LPS, are referred to its infection and reproductive capacity, and play an important role in the cell immune response. This review will focus on the interactions between the major virulence factors of L. pneumophila and its pathogenicity, and discuss implications for the study of the immune detection mechanisms. 【Key words 】 Legionella pneumophila; Virulence factors; Innate immunity; Dot/IcmⅣtype secretion system 1976 年，在美国费城退伍军人大会上，由嗜