《Chapter5BloodandMPS》-课件设计(公开).ppt

Chapter 5 Blood lymph Zhai Xiao Yue Department of Histology and Embryology Chapter 5 blood and MPS Composition of blood Structure and function of the elements of blood Mononuclear Phagocyte System Haemopoiesis Erythrocyte (red blood cell, RBC) Biconcave discs 双凹圆盘状 7.5~8.5μm in diameter No nuclei and no organelles Filled with hemoglobin (Hb), red colored Life span: 120 days Function：exchange of O2 and CO2 网织红细胞 reticulocyte： 煌焦油蓝染色——ribosomes fine meshwork 0.5%~1% Leucocytes General features in comparison to RBC Round in shape with nucleus and organelles No hemoglobin (no color) Pass through the capillaries into surrounding tissues. Short life span Motility: (Amoeboid movement) neutrophils and monocytes are most active phagocytosis Classification of leukocytes (WBC) Neutrophils 中性粒细胞 60-70 % of the total circulating leukocytes. 10~12 μm in diameter, a highly polymorphous nucleus with 2-5 sausage-shaped lobes Cytoplasm: weak pink, fine neutrophilic granules (acidic basic dyes) 嗜天青颗粒 azurophilic granules：20%，big，pale purple：lysosomes, acid hydrolases myeloperoxidase（髓过氧化物酶） Specific granules: 80%, small, 吞噬素、溶菌酶 stimulate an inflammatory reaction Life span: 15 hours in blood, 2-3 days in CoT Emigration（游出）and phagocytosis(吞噬). Eosinophils 嗜酸性粒细胞 0.5-3 % of the leukocyte population 10-15 μm in diameter, LM: coarse, pink staining granules in cytoplasm, two lobe nucleus. EM: granules: ly., heterogeneous crystal in it: ACPase, peroxidase, histaminase Emigration, secretion, phagocytosis counteract parasite and alleviate the allergic reaction life span: in blood a few days, in Cot 8-12d Basophils 嗜碱性粒细胞 0-1% of blood leukocytes. 10~12μm in diameter, LM: S-shaped nucleus, large, dark blue-staining granules, which are uneven in size and distribution, and matechromasia. EM: uneven electron density granules. Granules contains heparin, histamine, chondroitin sulphate, leukotriene 3 etc.. Mobile and phagocytic. And being involved in an allergic and inflammatory re