钛系生物医用材料表面粗糙度影响细胞黏附的新进展-中国科学技术.PDF

第 44 卷第 7 期 机 械 工 程 学 报 Vol.44 No.7 2008 年 7 月 CHINESE JOURNAL OF MECHANICAL ENGINEERING Jul. 2008 钛系生物医用材料表面粗糙度影响 细胞黏附的新进展* 梁迎春 宋代平 陈明君 白清顺 (哈尔滨工业大学精密工程研究所 哈尔滨 150001) 摘要：详细介绍粗糙表面细胞的黏附机理，结合表面加工方法较全面地总结和分析钛系材料不同表面粗糙度对细胞黏附的影 响及细胞黏附的表面粗糙度模型。综述表明：粗糙表面通过改变表面力场、表面电荷和表面能、增加比表面积及表面缺陷等 方式促进细胞在植入体表面的黏附；钛系材料表面粗糙度对不同细胞黏附的影响不同，粗糙表面可促进细胞基因表达；由于 表面加工方法造成表面化学状态变化并影响表面电荷和表面能，所以应根据不同的表面加工方法来设计植入体的表面形貌， 以获得适合细胞黏附的表面粗糙度。此外，探讨钛表面细胞吸附的分子动力学研究方法，结果显示可利用分子动力学方法在 分子水平研究表面特征对蛋白质和细胞黏附的影响机理。 关键词：钛系生物医用材料 表面粗糙度 细胞黏附 生物分子动力学仿真 中图分类号：TG146.2 New Development on Effect of Surface Roughness of Ti-material for Biomedical Applications on Cell Adhesion LIANG Yingchun SONG Daiping CHEN Mingjun BAI Qingshun (Precision Engineering Research Institute, Harbin Institute of Technology, Harbin 150001) Abstract ：The mechanisms of cell adhesion on rough surface are introduced in detail, the effects of various roughness of Ti-material surface on cell adhesion and the models of effects of surface roughness on cell adhesion are summarized and analyzed comprehensively by taking into consideration surface processing methods. The summary shows that the rough surface promotes cell adhesion by altering surface force field, surface charge and surface energy, increasing specific surface area and surface defect etc. The surface roughness of Ti-material has different effect on adhesion of different cell types, and the rough surface promotes the expression of cell genes. Because surface processing can change the surface chemistry and affect surface charge and energy, surface processing methods should be taken into account in order to design the implant surface morphology with the proper surface roughness for cell adhe