2-现子代医药生物技术概论2012.pptVIP

* * * In 2000, Tom Steiz and Peter Moor’s groups at Yale solved the crystal structure of the complexes of the large subunit with the substrate analog and suggested that the 23S rRNA is a peptidyl transferase in the ribosome. The closest approach of polypeptides to the peptidyl transferase active site marked by the Yarus inhibitor, CCdA-p-Puro. Right side: A view of the active site with the RNA removed. The phosphate of the Yarus analog and the proteins whose extensions are closest to the inhibitor are shown in ribbon with their closest side chains in all atom representation. The distances, in