3nucle册otidessynthsis.pptVIP

Biosynthesis and Degradation of Nucleotides Contents De novo purine nucleotide synthesis De novo pyrimidine nucleotide synthesis Nucleoside monophoshates are converted to nucleoside triphosphates Ribonucleotides are the precursors of deoxy-ribonucleotides Degradation of purine and pyrimidine The salvage pathways for purine and pyrimidine Many chemotherapeutic agents target enzymes in the nucleotide biosynthetic pathways Two types of pathway lead to nucleotides De novo synthesis of nucleotides begins with their metabolic precursors: amino acids, ribose 5-phosphate, NH3, and CO2. Salvage path