经导管射频消融去肾交感神经术对高血压犬左室肥厚与VEGFR1-PKG+I-Calcineurin通路的影响.pdfVIP

kinase Calcineurin cGMP—dependentprotein typeI(PKG—I)，and wereexamined． expression the animals n=l，SHAM Results：1．Duringstudy,threedied(RDN and n521 werethereforeexcludedfromthefinal 3months analysis．At timeof tobaselineandcontrol feeding，compared group，bothRDN(n=9) andSHAM of and increase group(n=8)gainedsignificant bodyweight blood ventricularmassindex pressure(p0．05)．Inaddition，left increasedwhileE／Aratio significantly decreased(all remarkedly monthsafterrenal p0．05)．Six denervation，bloodpressure，left ventricular massindexdecreasedwhereasE／Aratio increased significantly(all actualleftventricularmassinSHAM p0．05)．2．The was thancontrol to groupsignificantlyhigher SHAM ventricularmassinRDN was lower group，left groupsignificantly toRDN inSHAMshowedthat (p0．05)．3．Comparedgroup，HE group the cross—sectionalareawas myocardial significantlylarger(p0．05)； EMrevealedthatthe filamentswerenot myocardial intact，focallysis were were andshowedobvious evident，mitochondrias